The wedding took place at the Tokyo Institute of Technology; live human guests were in attendance, along with an MC and a priest. See Sal and Nene get hitched in the following video:
(Sal9000 marries Nene Anegasaki video)
Science fiction fans are not entirely unprepared for the sight of a real person marrying an anime character, thanks to the works of writers like William Gibson. He popularized the idea of a relationship with a virtual person in his 1996 novel Idoru, in which a virtual person, an idoru or idol-singer, seems so real to fans that some of them want to marry her.
Gaia - Why Stop With Just The Earth?
'But the stars are only atoms in larger space, and in that larger space the star-atoms could combine to form living matter, thinking matter, couldn't they?' - Robert Castle, 1939.
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SpaceX Intros Extravehicular Activity Suit
'Provision had been made to meet the terrific cold which we knew would be encountered the moment we had passed beyond the atmosphere.'
Gaia - Why Stop With Just The Earth?
'But the stars are only atoms in larger space, and in that larger space the star-atoms could combine to form living matter, thinking matter, couldn't they?'
Microsoft VASA-1 Creates Personal Video From A Photo
'...to build up a video picture would require, say, ten million decisions every second. Mike, you're so fast I can't even think about it. But you aren't that fast.'