Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
The Most Complex Synthetic Biology Circuit
MIT researchers have created what is being called the most complex synthetic biology circuit ever built.
Synthetic biologists design cellular circuits that can perform new functions, such as sensing environmental conditions, using genes as interchangeable parts. However, most of the circuits designed so far have been limited by the difficulty in assembling genetic components that don’t interfere with each other.
(4-input AND gate)
Unlike electronic circuits on a silicon chip, biological circuits inside a cell cannot be physically isolated from one another. “The cell is sort of a burrito. It has everything mixed together,” says Christopher Voigt, an associate professor of biological engineering at MIT.Because all the cellular machinery for reading genes and synthesizing proteins is jumbled together, researchers have to be careful that proteins that control one part of their synthetic circuit don’t hinder other parts of the circuit.
Voigt and his students have now developed circuit components that don’t interfere with one another, allowing them to produce the most complex synthetic circuit ever built. The circuit, described in the Oct. 7 issue of Nature, integrates four sensors for different molecules. Such circuits could be used in cells to precisely monitor their environments and respond appropriately.
“It’s incredibly complex, stitching together all these pieces,” says Voigt, who is co-director of the Synthetic Biology Center at MIT. Larger circuits would require computer programs that Voigt and his students are now developing, which should allow them to combine hundreds of circuits in new and useful ways.
The pathway consists of three components: an activator, a promoter and a chaperone. A promoter is a region of DNA where proteins bind to initiate transcription of a gene. An activator is one such protein. Some activators also require a chaperone protein before they can bind to DNA to initiate transcription.
Fans of science fiction writer Greg Bear recall the living "biologics" from his 1984 novel Blood Music:
Why limit oneself to silicon and protein and biochips a hundreth of a millimeter wide, when in almost every living cell there was already a functioning computer with a huge memory? A mammallian cell had a DNA complement of several million base pairs, each acting as a piece of information. What was reproduction, after all, but a compterized biological process of enormous complexity and reliability? The earliest biologic strings had been inserted into E. coli bacteria as circular plasmids...
(Read more about Greg Bear's biologics)
Via Kurzweil AI and MIT.
Scroll down for more stories in the same category. (Story submitted 10/8/2012)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Biology ")
Lunar Biorepository Proposed For Cryo-Preservation Of Earth Species
'...there was no one alive who had ever seen them. But they existed in the Life Bank.' - John Varley, 1977.
Let's Make Slaver Sunflowers! Engineering Plants To Reflect Light
'The mirror-blossom was a terrible weapon.' - Larry Niven, 1965.
Machete-Wielding Philodendron Isn't Going To Take It Anymore
'The tree ended its wild larruping, stood like a dreaming giant liable to wake into frenzy at any moment.' - Eric Frank Russell, 1943.
Tsunami Forecasts Improved By Ionosphere Signals
'Swifter than any tide could ebb, the water was receding from the shore.'
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
LLM 'Cognitive Core' Now Evolving
'Their only check on the growth and development of Vulcan 3 lay in two clues: the amount of rock thrown up to the surface... and the amount of the raw materials and tools and parts which the computer requested.'
Has Elon Musk Given Up On Mars?
'There ain't no such thing as a free lunch.'
Bacteria Turns Plastic Into Pain Relief? That Gives Me An Idea.
'I guess there's nobody round this table who doesn't have a Crosswell [tapeworm] working for him in the small intestine.'
When Your Child's Best Friend Is An AI
'Figments of his mind in one sense, of course, for he had shaped them...'
China's Drone Mothership Can Carry 100 Drones
'So the parent drone carries a spotter that it launches...'
Drones Recharge In Mid-Air Like Jets Refuel!
'...nurse drones that would cruise around dumping large amounts of power into randomly selected pods.'
Australian Authors Reject AI Training Of Llama
'It's done with a flip of the third joint of the tentacle on the down beat.'
Is China Mining Helium-3 On The Moon's Farside?
'...for months Grantline bores had dug into the cliff.'
Maybe It's Too Soon To Require Autonomous Mode
'I hope all those other cars are on automatic,' he said anxiously.
Is Agentic AI The Wrong Kind Of Smartness?
'It’s smart enough to go wrong in very complicated ways, but not smart enough to help us find out what’s wrong.'
Heat Waver - The First Ever Combo Solar Collector And Wind Turbine
'...like a spray of tulips mounted fanwise.'
Tesla 'Fleet Response Agents' Bolster FSD Autonomy
'You hate the whole idea that some bored drone pusher in a remote driving centre has got your life... in his hands.'
Mori3 Autonomous Shapeshifting Robot
'My homeland is being threatened by the Replicators. Thus far all attempts to stop them have failed.'
Tesla Seeks 'Tesla Robotaxi' And 'Robobus' Trademarks Ignoring Prior Art
'A robobus had just rolled up to the curb.'
Scary Grid Safety Robots
'The ultimate horror for our paranoid culture...'
Does AI Provide A Way Forward For Talk Therapy
'And there in the next room by the sofa sat a familiar suitcase, that of his psychiatrist Dr. Smile.'
