Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Epigenetic Memory's On/Off Switch Found
Epigenetics is the study of inheritable changes in gene expression not directly coded in our DNA. It appears that our life experiences can be passed on to our children, and to future generations, by this mechanism.
(From Transgenerational Small RNA Inheritance)
The duration of epigenetic responses underpinning
transgenerational inheritance is determined by an active
mechanism relying on the production of small RNAs
and modulation of RNAi factors, dictating whether ancestral
RNAi responses would be memorized or forgotten.
(credit: Leah Houri-Ze’evi et al./Cell)
“Until now, it has been assumed that a passive dilution or decay governs the inheritance of epigenetic responses,” said Oded Rechavi, PhD, from TAU’s Faculty of Life Sciences and Sagol School of Neuroscience. “But we showed that there is an active process that regulates epigenetic inheritance down through generations.”The scientists discovered that specific genes, which they named “MOTEK” (Modified Transgenerational Epigenetic Kinetics), were involved in turning epigenetic transmissions on and off.
“We discovered how to manipulate the transgenerational duration of epigenetic inheritance in worms by switching ‘on’ and ‘off’ the small RNAs that worms use to regulate [these] genes,” said Rechavi.*
These switches are controlled by a feedback interaction between gene-regulating small RNAs, which are inheritable, and the MOTEK genes that are required to produce and transmit these small RNAs across generations.
The feedback determines whether epigenetic memory will continue to the progeny or not, and how long each epigenetic response will last.
The first time I read about this idea was in an excellent series of fantasy novels by Barbara Hambly. In her 1982 Darwath trilogy, she writes about how wizards of several thousand years ago succeeded in tying information to the DNA of selected individuals. In the story, several people from 1980's California find themselves transported across the Void to another planet and the Realm of Darwath. They face a deadly species of queerly magical beings - the Dark - who destroyed civilization thousands of years ago. Everything that was made of paper (like books and records) were burned to stave off attacks by the Dark. Tying memories to a few suitable bloodlines was the only way to preserve a record of that period that would endure.
"We have all talked of the heritable memories of the House of Dare," she went on... maybe the old wizards, the engineers who raised the Keep, knew that records do get lost, especially when, as you said, fire is the principal weapon."Gil's finger stabbed out like a sword. "They tied the memory to the bloodline and that was their record! A record that wouldn't get lost and couldn't be destroyed."
Via KurzweilAI.
Scroll down for more stories in the same category. (Story submitted 3/29/2016)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Biology ")
Black Fungus Blocks Radiation
'You were surrounded by Astrophage most of the time' - Andy Weir, 2021.
Lunar Biorepository Proposed For Cryo-Preservation Of Earth Species
'...there was no one alive who had ever seen them. But they existed in the Life Bank.' - John Varley, 1977.
Let's Make Slaver Sunflowers! Engineering Plants To Reflect Light
'The mirror-blossom was a terrible weapon.' - Larry Niven, 1965.
Machete-Wielding Philodendron Isn't Going To Take It Anymore
'The tree ended its wild larruping, stood like a dreaming giant liable to wake into frenzy at any moment.' - Eric Frank Russell, 1943.
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
FTC: Says Ring Employees Illegally Surveilled Customers
'Then she looked up with a smile and moved closer to the camera.'
Switzerland May Cap Population At Ten Million
'The population of Castle Hagedorn was fixed...'
Project Silica Offers 'Long-Term' Digital Storage
'... folios and tapes and playable discs of platinum alloy.'
Can 'Tactical Umbrellas' Shield One From Drones
'... another corner of his mind began to think about the shields.'
Crystalline Structures In Space, You Say?
A massive space borne lifeform from ST:TNG.
Garçon! A Menu For Artemis II, S'il Vous Plaît
'Michel Ardan, as a Frenchman, was declared chief cook, an important function, which raised no rival.'
Amazing Photonic Crystal Light Sail
'That sail will be twenty thousand miles at the wide part.'
Blue Collar AI Goes To Work To Mine Its Own Crypto
Blue collar bot.
Rogue AI Replicated Itself
'Sapiro’s computer just kept dialing at random, hanging up on humans, until it got a fellow computer of the same type as itself.'
HandelBot Helps Two-Handed Robots Learn Piano
'I request that you feed the correlation between those dots and the levers of the panel into my memory banks.'
Woven Fiber Electronic Skin For Robots
'... all the feel and appearance of human flesh and epidermis.'
When AI Takes Its First Breath
Any suggestions?
Chinese Aircar Light And Airy, Not For Blade Runners
Daytime version.
The Morphing Wheel And The Smartwheel
'If you surf over a bump, the spokes contract to roll over it.'
Transporting Antimatter
'...drawing plans for the magnetic tongs and bed plates and relays.'
Polish Turns Your Nail Into A Stylus
'He wrote on it, using the pointed fingernail of his right forefinger...'
