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Bone-Building Drug Evenity Approved
Romosozumab, marketed under the name Evenity, has been approved by the FDA. It helps build new bone, and has been approved for postmenopausal women who have fractures, are at very high risk for fractures or haven’t responded to other treatments.
In clinical trials, romosozumab increased bone density in the spine as much as 15% – about the amount seen in healthy teens – and cut down on spinal fractures. Patients who switched to a bisphosphonate for another year also had fewer fractures in the wrist and hip.
But Geoffrey Porges, MD, a leading biotech analyst in Boston, points out that the number of hip fractures in the study decreased by only 25%, leaving many women still vulnerable. (According to the CDC, 1 in 5 women die of complications from a hip fracture within a year of their injury.)
Science fiction authors thought about bone-building compounds, if not in the same context, as early as 1932, to aid in the exploration of heavy gravity planets like Jupiter. Consider the following, from A Conquest of Two Worlds, by Edmond Hamilton.
Published by Wonder Stories in 1932.
Romosozumab works by blocking sclerostin – a protein that stops bone from forming. The drug is given by injection once a month for a year (after 12 months, it loses its effectiveness).
(Via Arthritis.org.)
Earth's scientists solved the problem to some extent by devising rigid metallic clothing not unlike armor which would support the interior human structure against Jupiter's pull. Crane's men were also administered compounds devised by the biochemists for the rapid building of bone to strengthen the skeleton structure...
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