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"It is change ... that is the dominant factor in society today... the world as it will be. This means that ... every man must take on a science fictional way of thinking.""
- Isaac Asimov

Mutant  
  A new organism resulting from an alteration in the DNA sequence of its genome or chromosome.  

As far as I know, the first instance of this word in science fiction.

His companion definitely was not human. He was a whole chapter out of a nightmare. Evolution had done its worst as far as he was concerned. Everything about him was unhuman, from the tough warty skin that inclosed him, through the rubbery dangling fingers to the crowning horror of all - a single round, unwinking lidless eye set underneath a broad expanse of greenish forehead.


(Mutants from The 100th Generation)

...Lorn must have been a mutant, somewhere in the earlier generations, that had bred true and increased its divergence from generation to generation.

Technovelgy from The 100th Generation, by Nat Schachner.
Published by Astounding Science Fiction in 1934
Additional resources -

Compare to mutation from The Man Who Evolved (1931) by Edmond Hamilton.

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Additional resources:
  More Ideas and Technology from The 100th Generation
  More Ideas and Technology by Nat Schachner
  Tech news articles related to The 100th Generation
  Tech news articles related to works by Nat Schachner

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Science Fiction in the News

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'...the rocket’s landing-arms automatically unfolded.'

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'...points and patches of light... sliding all over their faces in a programmed manner that had been designed to foil facial recognition systems.'

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'The crawling, exploring object was V-Stephen's surgeon-hand...'

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'...the combined Wind-Suncatcher, like a spray of tulips mounted fanwise.'

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'I went to the control room where the three other men were manipulating their mechanical men.'

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'The automatic massager began to fumble gently...'

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'The low-slung monorail car, straddling its single track, bored through the shadows on a slowly rising course.'

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'It was a smooth ovoid floating a few inches from the floor...'

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'... he thrust in his charging arm to replenish his store of energy.'

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'...the terrible Jovian gravity that made each movement an effort.'

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