Science Fiction Dictionary
A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

 

Mice Get Smarter By Losing Cdk5 Enzyme

Just when you think you have a better mousetrap - they build a smarter mouse. Texas University research suggests that mice with the Cdk5 enzyme knocked out learn faster and detect changes in their environment more rapidly. The study results were published in the journal Nature Neuroscience this week.

"It's pretty rare that you make mice 'smarter,' so there are a lot of cognitive implications," the study's senior author, Dr. James Bibb, said in a news release.

"Everything is more meaningful to these mice," he said. "The increase in sensitivity to their surroundings seems to have made them smarter."

The key was removing the gene for Cdk5 only in the brain, and only after the mice had grown to adulthood. A technique called "conditional knock-out" was used, which results in a tissue-specific inactivation of a gene.

The reconfigured mice are better able to find their way through a water maze - and avoiding the electroshock parts. When crafty researchers altered the maze, the modified mice were the first to realize the change and learn the new structure.

This can be achieved by means of a recombinase, which is an enzyme that deletes the DNA fragment located between the two recombinase-specific sites. A mouse bearing the recombinase-specific sites is bred with a mouse expressing the recombinase. The tissue-specific expression of the recombinase allows the inactivation of the gene of interest only in the tissue where the recombinase is expressed

Like the rest of us, science fiction writers have diligently set up scenarios in which humans could become smarter. In Philip K. Dick's 1964 novel The Three Stigmata of Palmer Eldritch, people could actually get more brains if they wanted to be smarter. A procedure called E Therapy was performed to increase the size of their brains:

The man's head reminded Hnatt of a photograph he had once seen in a textbook; the photo had been labeled hydrocephalic. The same enlargement above the browline; it was clearly domelike and oddly fragile-looking and he saw at once why these well-to-do persons who had evolved were popularly called bubbleheads.
(Read more about bubbleheads)

Amazingly, researchers have been able to grow larger brains in mice; see the second part of Philip K. Dick's Bubblehead Brainiacs for details. Researchers have also tried creating mouse-human hybrids to make them smarter (mice, that is); see Mouse With Human Brain May Live for details.

Via CBC News; see also conditional knock out mouse.

Scroll down for more stories in the same category. (Story submitted 5/29/2007)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Biology ")

Baubotanik - Construction Botany - Builds Bridges
'A dwelling must be all of a unit—the walls, the drainage, the decor grown in!' - Jack Vance, 1954.

Mice Gestate In Mechanical Womb
'... in the Decanting Room, the newly-unbottled babes uttered their first yell of horror and amazement.' - Aldous Huxley, 1932.

Worlds With Underground Oceans More Conducive To Life
'There is life on Europa.' - Arthur C. Clarke, 1982.

Monkey Gets A Bigger Brain, Thanks To Human Gene
'It's a madhouse! a madhouse!' - Planet of the Apes, 1968.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

Science Fiction Timeline
1600-1899
1900-1939
1940's   1950's
1960's   1970's
1980's   1990's
2000's   2010's

Current News

NAVER Labs Haptic Device 2.0 Robot vs. IKEA
'... the two pairs of waldoes in the screen followed in exact, simultaneous parallelism.'

Spaceships Should Last So Long
'THE SPACE VESSEL was traveling swiftly… For over five thousand years they had Voyaged on and on.’

Shine On, Portable Wind Turbine
'Sometimes a man has a windmill on his roof...'

Amazing Indoor Robotic Drones Mimic Dolphins and Whales
'They circled the vast audiences, dancing, twittering, chirping...'

Space Station Shutters
'The sun-quilt was a patchwork of colors and materials on the inward side, but silvered on the outward side...'

Tiny Mining - Extract Precious Industrial Minerals From Your Own Body
'Jim, I saw them reduce four of my doctors and nurses into those little cubes!'

MIT Proposes Space Bubbles To Combat Climate Change, Misses The Point Of Space Bubbles
'Fats Jordan was hanging in the center of the Big Glass Balloon, hugging his guitar to his massive black belly above his purple shorts..'

Tianjin Solar Vehicle From Hanergy (2022) Looking Like Heinlein's (1940)
'When confronted by hills, or rough terrain, it did not stop, but simply slowed until the task demanded equaled its steady power output.'

Study Reveals Effect Of Space Travel On The Brain
'... the brain is no longer subjected to the accustomed pull, and it expands slightly in all directions.'

Sky Cruise Nuclear Powered Flying Hotel Concept
'... the huge air-freighter Jupiter.'

The Mojo Smart Contact Lens Experience
'... the lens displays would be useless without a wearable computer to do the graphics.'

Small Town Wants 60 License Plate Readers
'the registration number which the traffic control automatically photographed as she left the controlway...'

Lightyear 0 World's First Production-Ready Solar Car
'It could maintain a steady six miles per hour...'

AI Robots Excel At Trash Sorting And Recycling
'Then they press one of these here thirteen buttons...'

Could Increased Space Rocketry Damage The Ozone Layer?
'...without burning a single hydrocarbon molecule to injure the diseased atmosphere any further.'

Dyson's Secret Household Robots
'...work a human being does around a house.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.