Mice Get Smarter By Losing Cdk5 Enzyme

Just when you think you have a better mousetrap - they build a smarter mouse. Texas University research suggests that mice with the Cdk5 enzyme knocked out learn faster and detect changes in their environment more rapidly. The study results were published in the journal Nature Neuroscience this week.

"It's pretty rare that you make mice 'smarter,' so there are a lot of cognitive implications," the study's senior author, Dr. James Bibb, said in a news release.

"Everything is more meaningful to these mice," he said. "The increase in sensitivity to their surroundings seems to have made them smarter."

The key was removing the gene for Cdk5 only in the brain, and only after the mice had grown to adulthood. A technique called "conditional knock-out" was used, which results in a tissue-specific inactivation of a gene.

The reconfigured mice are better able to find their way through a water maze - and avoiding the electroshock parts. When crafty researchers altered the maze, the modified mice were the first to realize the change and learn the new structure.

This can be achieved by means of a recombinase, which is an enzyme that deletes the DNA fragment located between the two recombinase-specific sites. A mouse bearing the recombinase-specific sites is bred with a mouse expressing the recombinase. The tissue-specific expression of the recombinase allows the inactivation of the gene of interest only in the tissue where the recombinase is expressed

Like the rest of us, science fiction writers have diligently set up scenarios in which humans could become smarter. In Philip K. Dick's 1964 novel The Three Stigmata of Palmer Eldritch, people could actually get more brains if they wanted to be smarter. A procedure called E Therapy was performed to increase the size of their brains:

The man's head reminded Hnatt of a photograph he had once seen in a textbook; the photo had been labeled hydrocephalic. The same enlargement above the browline; it was clearly domelike and oddly fragile-looking and he saw at once why these well-to-do persons who had evolved were popularly called bubbleheads.
(Read more about bubbleheads)

Amazingly, researchers have been able to grow larger brains in mice; see the second part of Philip K. Dick's Bubblehead Brainiacs for details. Researchers have also tried creating mouse-human hybrids to make them smarter (mice, that is); see Mouse With Human Brain May Live for details.

Via CBC News; see also conditional knock out mouse.

Scroll down for more stories in the same category. (Story submitted 5/29/2007)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Biology ")

Oil from Algae - Can It Be Done?
'We dump everything that's waste into the tanks, pump the oil off the top.' - Hal Clement, 1950.

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.

Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.'

Flying Dragon Robot Transforms In Mid-Air
Terrific prototype video.

Negative Matter Fluid Theorized In New Paper
'Of course, being negative matter, when you push it, it comes toward you..'

Grow Structures Upon Planetfall - Myco-Architecture
'They'll also start pulling in gases and liquids from the local atmosphere...'

MXene Hydrogel Skin For Robots Flexes And Senses
'The plastex swam and whirled like boiling toothpaste...'

EXPLORER, The First Total-Body Scanner
'The object is built up of an infinite series of plane layers, at the focus of the ray...'

UK Police AI To Stop Criminals Before They Strike
'... the computing mechanisms that studied and restructured the incoming material.'

Sonitus Audio Interface Positioned Beyond The Noise
'... an instrument having relatively small bit pieces adapted to be gripped between the teeth.'

Volvo's Self-Driving Mining Trucks
'A procession of automatic ore carts was racing over the bleak slag'

Audi Pop.Up Autonomous Electric Flying Car
'The cab was an egg-shaped bubble of light metals and plastics...'

Music Not Impossible (MNI) Vibrotactile Wearable Experience
Don't you want to experience the 'feely' effects?

Chinese Face Recognition Mistakes Bus Ad For Jaywalker
'... the imprint of her image on the telephoto cell.'

A Look Back At Apollo's Emergency Escape Vehicle
'A simple mechanism... it drove the iron ball through space like a ship.'

InMotion Glide 3 Electric Unicycle For The Last Mile
'...gyro-stabilized on a single wheel.'

China's Social Credit System - A Facebook-1984 Mashup
'Prestige, face, mana, repute, glory: the Sirenese word is strakh.'

Musk Declares Tesla Supercharger Capacity Will Double By Next Year
'Recharge the batteries... in almost every town and village...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.