Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Logic Gates Built Inside Living Cells
Caltech scientists announced that they had succeeded in building synthetic RNA logic gates inside living cells that actually sense molecules inside the cell.
The end result is that the drug acts as a switch, turning the ribozyme on and off. Making each of the two lobes sensitive to a different drug even created a biological AND switch; both drugs need to be present for an active ribozyme. But a ribozyme isn't necessarily easy to detect, so the authors made it obvious: they inserted their logic gates into a gene that encodes a messenger RNA that produces the Green Fluorescent protein (the protein that recently won folks a Nobel Prize). Now, when the ribozyme is active, the messenger RNA gets broken up and no GFP is made; otherwise, the cells glow green.
This setup allowed the creation of an OR logic system as well.
Several RNA sequences have been identified that bind small molecules, like the drug tetracycline. The authors inserted these into the extended lobes, such that the drug controlled the folding of the RNA. When tetracycline is present, the RNA would fold so that there was no active ribozyme. Remove the tetracycline, and the molecule would reshuffle so that the ribozyme became active.
(Signal Integration Schemes)
This advance could lead to a wide range of applications, since the method would work just as well inside the cells of mammals. Biocomputers in a human bloodstream could control "smart drugs" that activate only under particular circumstances. Sensor cells could be programmed to detect the precursors of diseases like cancer, and then "light up" to alert health care professionals.
SF writer Greg Bear wrote about this idea in his 1984 novel Blood Music; he called them "biologics:"
Why limit oneself to silicon and protein and biochips a hundreth of a millimeter wide, when in almost every living cell there was already a functioning computer with a huge memory?
Let's hope we don't wind up with what Bear called intellectual cells. From RNA-based logic gates compute inside cells.
Scroll down for more stories in the same category. (Story submitted 10/19/2008)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Biology ")
Black Fungus Blocks Radiation
'You were surrounded by Astrophage most of the time' - Andy Weir, 2021.
Lunar Biorepository Proposed For Cryo-Preservation Of Earth Species
'...there was no one alive who had ever seen them. But they existed in the Life Bank.' - John Varley, 1977.
Let's Make Slaver Sunflowers! Engineering Plants To Reflect Light
'The mirror-blossom was a terrible weapon.' - Larry Niven, 1965.
Machete-Wielding Philodendron Isn't Going To Take It Anymore
'The tree ended its wild larruping, stood like a dreaming giant liable to wake into frenzy at any moment.' - Eric Frank Russell, 1943.
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
Is It Time For A Connected Edge Node For AI Inference
'Buy a Little Dingbat... electropen, wrist watch, pocketphone, pocket radio, billfold ... all in one.'
Artificial Skin For Robots Is Coming Right Along
'... an elastic, tinted material that had all the feel and appearance of human flesh and epidermis.'
Robot Guard Dog On Duty
I might also be thinking of K-9 from Doctor Who.
Wearable Artificial Fabric Muscles
'It is remarkable that the long leverages of their machines are in most cases actuated by a sort of sham musculature...'
BrainBridge Actual Transplant Of Human Head Proposed
'Briquet’s head seemed to think that to find and attach a new body to her head was as easy as to fit and sew a new dress.'
Google's Nano Banana Pro Presents Handwritten Math Solutions
'...copy was turned out in a charming and entirely feminine handwriting.'
Edible Meat-Like Fungus Like Barbara Hambly's Slunch?
'It was almost unheard of for slunch to spread that fast...'
Sunday Robotics 'Memo' Bot Has Unique Training Glove
'He then started hand movements of definite pattern...'
Woman Marries Computer, Vonnegut's Dream Comes True
'Men are made of protoplasm... Lasts forever.'
Natural Gait With Prosthetic Connected To Nervous System
'The leg was to function, in a way, as a servo-mechanism operated by Larry’s brain...'
Spidery 'Walk Me' Toyota Autonomous Wheel Chair Like Star Wars
Walk along with the emperor.
Dancing Robots Taught Dance Moves
'A clockwork figure would be the thing for you...'
Proof Of Robothood - Not A Person
'Who are you people? - Show 'em.'
Indonesian Clans Battle
'The observation vehicle was of that peculiar variety used in conveying a large number of people across rough terrain.'
The 'Last Mile' In China Crowded With Delivery Robots
Yes, it's a delivery robot. On wheels.
Tornyol Microdrone Kills Mosquitoes
'The real border was defended by... a swarm of quasi-independent aerostats.'
