Micromasonry 'Biological Legos' Building New Organs

One of the problems with building your own organs from scratch is getting the 3-dimensional structure right. MIT-Harvard researchers are working on biological legos to grow a 3D organ.

The new technique, called micromasonry, involves tiny blobs of a gel-like material. Each tiny blob contains individual cells; the blobs stick together in a desired structure.


( half sphere of polymer cubes built by MIT-Harvard researchers )

A variety of techniques have been evolved for printing two-dimensional strips of organic matter (see Hungry? Print Yourself Some Bacon and Cultured Meat Straight From The Vat for two approaches).

"That works, but it often lacks a controlled microarchitecture," says Ali Khademhosseini, assistant professor at the MIT-Harvard Division of Health Sciences and Technology (HST), is also an assistant professor at Brigham and Women's Hospital. "You don't get tissues with the same complexity as normal tissues."

Gomez Fernandez and Khademhosseini have used their technique to build tiny tubes that could function as capillaries, which could provide an engineered organ with its blood supply.

The HST researchers built their "biological Legos" by encapsulating cells within a polymer called polyethylene glycol (PEG), which has many medical uses. Their version of the polymer is a liquid that becomes a gel when illuminated, so when the PEG-coated cells are exposed to light, the polymer hardens and encases the cells in cubes with side lengths ranging from 100 to 500 millionths of a meter.

Once the cells are in cube form, they can be arranged in specific shapes using templates made of PDMS, a silicon-based polymer used in many medical devices. Both template and cell cubes are coated again with the PEG polymer, which acts as a glue that holds the cubes together as they pack themselves tightly onto the scaffold surface.

After the cubes are arranged properly, they are illuminated again, and the liquid holding the cubes together solidifies. When the template is removed, the cubes hold their new structure.

SF fans have waited a long time for artificially grown organs; Larry Niven wrote about the idea in his 1968 novel A Gift From Earth.

From Science Daily.

Scroll down for more stories in the same category. (Story submitted 5/16/2010)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...' - Larry Niven, 1968.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.' - Frank Herbert, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

North Focals Smart Glasses Provide Augmented Reality In Style
'The world ... is drenched in unfamiliar information all the way to the horizon.'

Tesla Driver Caught Napping Behind The Wheel
'Mary Risling settled back for a little nap...'

Hayabusa 2 To Begin Asteroid Mining
'We must dig down, and then doubtless we shall find the metal.'

Ionocraft Drone Powered By Electrohydrodynamic Thrust
'He saw one hiss by him as he rounded the corner, trailing a short whip antenna...'

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.'

BloxVox Mutes Cellphone Convos
It's the polite thing to do, and has been the polite thing to do for about four generations.

Superfast Replicator: Volumetric Additive Manufacturing
I can't wait. Bring it on.

DNA May Contain Malware
'You were told to embed the logical pathogen.'

I Can't Resist Worm Robots
'Seen close it was not completely flexible...'

Rplate Digital License Plates Now Legal In Michigan
'Gragg's digital ink license plates ...'

Can Musk Starship Astronauts Use Magnetic Boots?
'Walking awkwardly in the magnetic boots that held him to the black mass of meteoric iron...'

Giant Dolphin Spotted On Jupiter!
'Now at last he could appreciate its real size and complexity...'

Musk's Starship An SF Fan's Dream Come True
Perfect for testing, perfect for fans!

TinyMobileRobots Are Sewer Sentinels
Every movie monster gets its start someplace.

Fishy Facial Recognition Now Possible
'Palenkis can identify random line patterns better than any other species in the universe.'

Spicy Tomatoes Created With Genetic Engineering
How about mashed potatoes and brown gravy?

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.