Deleting Gene Makes Mice Smarter
Disabling the RGS14 gene in mice improves their ability to learn and remember, according to a study published by Emory University's School of Medicine researchers.
The researchers were surprised to find that, in mice with a disabled RGS14 gene, the CA2 region was now capable of "robust" long-term potentiation, meaning that in response to electrical stimulation, neurons there had stronger connections. On top of that, the ability of the gene-altered mice to recognize objects previously placed in their cages was enhanced, compared to normal mice. They also learned more quickly to navigate through a water maze to a hidden escape platform by remembering visual cues.
"A big question this research raises is why would we, or mice, have a gene that makes us less smart – a Homer Simpson gene?" John Hepler, PhD, professor of pharmacology at Emory University School of Medicine, says. "I believe that we are not really seeing the full picture. RGS14 may be a key control gene in a part of the brain that, when missing or disabled, knocks brain signals important for learning and memory out of balance."
The lack of RGS14 doesn't seem to hurt the altered mice, but it is still possible that they have their brain functions changed in a way that researchers have not yet been able to spot. Besides being resistant to injury by seizure, certain types of CA2 neurons are lost in schizophrenia, and loss of another gene turned on primarily in the CA2 region leads to altered social behaviors,
RGS14, which is also found in humans, was identified more than a decade ago.
Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.
(Flowers For Algeron)
Read more at RDMag; thanks to Winchell Chung for prodding me to do this article.
Scroll down for more stories in the same category. (Story submitted 9/23/2010)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 4 )
Related News Stories -
Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.
Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.
Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.
Researchers Create Bowls, Coils, Ripples Of Living Tissue
'... biological robots were not living creatures.' - Arthur C. Clarke, 1972.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Jaguar I-Pace Audible Vehicle Alert System For EVs
'Of course not a vehicle moved by means of internal explosions of a derivative of rock oil...'
Autonomous 'Fiberbots' Weave Large Structures
'It extrudes material like a spider.'
Birds Aren't Real - Wake Up, California! (With Bird Watching Guide)
'When he had first built them, they had been crude indeed, flying mechanisms with little more than a reflex-response unit.'
Self-Healing Material Pulls Carbon Out Of The Air
'... could seal the punctures.'
IRL Glasses Block Screens, Limit Vision To Real Life
'If you couldn't see the ads, how would you know what was fashionable?'
Testing The Single-Person Spacecraft
'...the lower part of the suit was simply a rigid cylinder.'
Shapeshifting Materials Transform By Light
'Its lines wavered, flowed, and then painfully reformed.'
Fully Automated Farm Iron Ox Hydroponics
'Had these machines in some incredible fashion been provided with brains?'
BrainNet Social Network Of Brains
'I used my implant to tell MILLIE what we wanted and she took care of it'
Phil Nuyttnn's City Under The Sea
'Under the lower roof there was no water, but a clear and luminous atmosphere...'
IONITY Opens First 10 Fast-Charging Stations
'Recharge the batteries... in almost every town and village...'
Superstrong Multilayer Metal-Graphene Composite Material
Negligible increase in weight increased material strength by hundreds of times.
Deepfakes Imperil Democracy (George Orwell, Right Again)
'All history was a palimpsest, scraped clean and reinscribed exactly as often as was necessary.'
String Art Courtesy Of Robot Artist
The number of different ways to span a thread between a larger number of hooks is astronomical.
Still Wondering If You'd Work For A Robot Boss?
'This is all coming to you courtesy of the simstim unit wired into your deck, of course.'
World's First Autonomous Tram In Germany
What's it like for autonomous trams when they're turned off at night?
More SF in the News Stories
More Beyond Technovelgy science news stories