Deleting Gene Makes Mice Smarter
Disabling the RGS14 gene in mice improves their ability to learn and remember, according to a study published by Emory University's School of Medicine researchers.
The researchers were surprised to find that, in mice with a disabled RGS14 gene, the CA2 region was now capable of "robust" long-term potentiation, meaning that in response to electrical stimulation, neurons there had stronger connections. On top of that, the ability of the gene-altered mice to recognize objects previously placed in their cages was enhanced, compared to normal mice. They also learned more quickly to navigate through a water maze to a hidden escape platform by remembering visual cues.
"A big question this research raises is why would we, or mice, have a gene that makes us less smart – a Homer Simpson gene?" John Hepler, PhD, professor of pharmacology at Emory University School of Medicine, says. "I believe that we are not really seeing the full picture. RGS14 may be a key control gene in a part of the brain that, when missing or disabled, knocks brain signals important for learning and memory out of balance."
The lack of RGS14 doesn't seem to hurt the altered mice, but it is still possible that they have their brain functions changed in a way that researchers have not yet been able to spot. Besides being resistant to injury by seizure, certain types of CA2 neurons are lost in schizophrenia, and loss of another gene turned on primarily in the CA2 region leads to altered social behaviors,
RGS14, which is also found in humans, was identified more than a decade ago.
Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.
(Flowers For Algeron)
Read more at RDMag; thanks to Winchell Chung for prodding me to do this article.
Scroll down for more stories in the same category. (Story submitted 9/23/2010)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 4 )
Related News Stories -
Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.
Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.
Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.
Researchers Create Bowls, Coils, Ripples Of Living Tissue
'... biological robots were not living creatures.' - Arthur C. Clarke, 1972.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Las Vegas Humans Ready To Strike Over Robots
'A worker replaced by a nubot... had to be compensated.'
You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.'
Elon Musk Seeks To Create 1941 Heinlein Speedster
'The car surged and lifted, clearing its top by a negligible margin.'
Somnox Sleep Robot - Your Sleepytime Cuddlebot
Science fiction authors are serious about sleep, too.
Real-Life Macau or Ghost In The Shell
Art imitates life imitates art.
Has Climate Change Already Been Solved By Aliens?
'I had explained," said Nessus, "that our civilisation was dying in its own waste heat.'
First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.
VirtualHome: Teaching Robots To Do Chores Around The House
'Just what did I want Flexible Frank to do? - any work a human being does around a house.'
Messaging Extraterrestrial Intelligence (METI) Workshop
SF writers have thought about this since the 19th century.
Nanorobots Roam Your Bloodstream, Cleaning It
Too bad they won't have lasers, though...
Galini 3D Printed Sleeping Pod Tiny Houses
'The houses are prefabricated units...'
MIT Boffins Create Psychopath AI On Purpose
There's a lesson in this for neural net AI engineers everywhere.
Skin Electronics 3D Printed
'June's body is a tracery of lambent lines, like some arcane capillary circuitry...'
Artificial Sensory Neurons For Prosthetics, Robots
Great for humans and robots!
China Uses Artificial Intelligence To Grade Student Papers
Looks like the City Fathers are starting to take over China's education system.
Electronic Tongues Will Rule The Kitchen
'Install taste buds in the end of one tentacle...'
More SF in the News Stories
More Beyond Technovelgy science news stories