Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Can Sirtuins Block The Aging Process?
SIRT1 is an enzyme in the class of molecules called Sirtuins. Significant research shows that activation of sirtuins reduces cellular aging through its interaction with other cellular master switches such as FOXO3a and PGC-1a.
Resveratrol (a polyphenol found in red wine and grapes) may be a weak natural activator of sirutin and has been linked in some studies with the extension of animal lifespan. Data on these sitruin activators or STACs is inconsistent. “The legitimacy of STACs as direct SIRT1 activators has been widely debated,” write the authors.
In the present study, the researchers developed a sirtuin activation assay. They tested 117 experimental STACs and were able to prove that the enzyme could be directly activated and uncovered the exact molecular mechanism by which this occurred.
The authors conclude:
Sinclair believes that safe drugs of this class could be available for testing in as little as five years.
Mankind has wished for a Fountain of Youth for a long time. Science fiction writers have expressed their longing for a scientific basis to anti-aging. One such example is the Sprung-Samser treatment from Roger Zelazny's 1966 novel This Immortal:
Fans of the Cities in Flight novels by James Blish may recall the anti-agathic drugs that were provided to a select few members of the cities.
From Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators via Extreme Longevity.
“At the cellular level,” explain the authors. “SIRT1 controls DNA repair and apoptosis, circadian clocks, inflammatory pathways, insulin secretion, and mitochondrial biogenesis”
The data presented here favor a mechanism of direct “assisted allosteric activation” mediated by an N-terminal activation domain in SIRT1 that is responsible for at least some of the physiological effects of STACs. Thus, allosteric activation of SIRT1 by STACs remains a viable therapeutic intervention strategy for many diseases associated with aging.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says Sinclair, from Harvard University. “In effect, they would slow ageing.” He points out this research shows something never previously described ”In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” he said.
Eighty or ninety or more, looking about forty, [Hasan] could still act thirty. the Sprung-Samser treatments had found highly responsive material. It's not often that way. Almost never, in fact. They put some people into accelerated anaphylactic shock for no apparent reason, and even an intracardial blast of adrenalin won't haul them back; others, most others, they freeze at five or six decades. But some rare ones actually grow younger when they take the series - about one in a hundred thousand.
Scroll down for more stories in the same category. (Story submitted 3/10/2013)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Medical ")
MIT Computerized Bionic Leg Is Part Of The User
'The leg was to function, in a way, as a servo-mechanism operated by Larry’s brain, through the mediation of the electronic brain in the leg.' - Charles Recour, 1949.
Bone-Building Drug Evenity Approved
'Compounds devised by the biochemists for the rapid building of bone...' - Edmond Hamilton, 1932.
BrainBridge Concept Transplant Of Human Head Proposed
'Briquet’s head seemed to think that to find and attach a new body to her head was as easy as to fit and sew a new dress.' - Alexander Belaev (1925)
Natural Gait With Prosthetic Connected To Nervous System
'The leg was to function, in a way, as a servo-mechanism operated by Larry’s brain...' - Charles Recour, 1949.
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
FTC: Says Ring Employees Illegally Surveilled Customers
'Then she looked up with a smile and moved closer to the camera.'
Switzerland May Cap Population At Ten Million
'The population of Castle Hagedorn was fixed...'
Project Silica Offers 'Long-Term' Digital Storage
'... folios and tapes and playable discs of platinum alloy.'
Can 'Tactical Umbrellas' Shield One From Drones
'... another corner of his mind began to think about the shields.'
Crystalline Structures In Space, You Say?
A massive space borne lifeform from ST:TNG.
Garçon! A Menu For Artemis II, S'il Vous Plaît
'Michel Ardan, as a Frenchman, was declared chief cook, an important function, which raised no rival.'
Amazing Photonic Crystal Light Sail
'That sail will be twenty thousand miles at the wide part.'
Blue Collar AI Goes To Work To Mine Its Own Crypto
Blue collar bot.
Rogue AI Replicated Itself
'Sapiro’s computer just kept dialing at random, hanging up on humans, until it got a fellow computer of the same type as itself.'
HandelBot Helps Two-Handed Robots Learn Piano
'I request that you feed the correlation between those dots and the levers of the panel into my memory banks.'
Woven Fiber Electronic Skin For Robots
'... all the feel and appearance of human flesh and epidermis.'
When AI Takes Its First Breath
Any suggestions?
Chinese Aircar Light And Airy, Not For Blade Runners
Daytime version.
The Morphing Wheel And The Smartwheel
'If you surf over a bump, the spokes contract to roll over it.'
Transporting Antimatter
'...drawing plans for the magnetic tongs and bed plates and relays.'
Polish Turns Your Nail Into A Stylus
'He wrote on it, using the pointed fingernail of his right forefinger...'
