Can Sirtuins Block The Aging Process?
SIRT1 is an enzyme in the class of molecules called Sirtuins. Significant research shows that activation of sirtuins reduces cellular aging through its interaction with other cellular master switches such as FOXO3a and PGC-1a.
“At the cellular level,” explain the authors. “SIRT1 controls DNA repair and apoptosis, circadian clocks, inflammatory pathways, insulin secretion, and mitochondrial biogenesis”
Resveratrol (a polyphenol found in red wine and grapes) may be a weak natural activator of sirutin and has been linked in some studies with the extension of animal lifespan. Data on these sitruin activators or STACs is inconsistent. “The legitimacy of STACs as direct SIRT1 activators has been widely debated,” write the authors.
In the present study, the researchers developed a sirtuin activation assay. They tested 117 experimental STACs and were able to prove that the enzyme could be directly activated and uncovered the exact molecular mechanism by which this occurred.
The authors conclude:
The data presented here favor a mechanism of direct “assisted allosteric activation” mediated by an N-terminal activation domain in SIRT1 that is responsible for at least some of the physiological effects of STACs. Thus, allosteric activation of SIRT1 by STACs remains a viable therapeutic intervention strategy for many diseases associated with aging.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says Sinclair, from Harvard University. “In effect, they would slow ageing.” He points out this research shows something never previously described ”In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” he said.
Sinclair believes that safe drugs of this class could be available for testing in as little as five years.
Mankind has wished for a Fountain of Youth for a long time. Science fiction writers have expressed their longing for a scientific basis to anti-aging. One such example is the Sprung-Samser treatment from Roger Zelazny's 1966 novel This Immortal:
Eighty or ninety or more, looking about forty, [Hasan] could still act thirty. the Sprung-Samser treatments had found highly responsive material. It's not often that way. Almost never, in fact. They put some people into accelerated anaphylactic shock for no apparent reason, and even an intracardial blast of adrenalin won't haul them back; others, most others, they freeze at five or six decades. But some rare ones actually grow younger when they take the series - about one in a hundred thousand.
Fans of the Cities in Flight novels by James Blish may recall the anti-agathic drugs that were provided to a select few members of the cities.
From Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators via Extreme Longevity.
Scroll down for more stories in the same category. (Story submitted 3/10/2013)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
Vascularized Human Skin 3D Printed
Hey Fishboy! Three days and you're out!
China Accused Of Harvesting Organs From Unwanted Groups
'The death penalty was his immortality, and he would vote the death penalty for any crime at all.' Larry Niven, 1967.
Robothread Robotic Worms Crawling Through Your Brain
Perfect for clot-busting in the human brain. No Raquel Welch and no lasers, though.
Skin Electronics Can Show Electrocardiogram
'... the young men in the streets who applied polyimde OLED body film to their bared shoulders.' - Chen Qiufan, 2019.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Orbital Display's Low Earth Orbit Advertisements
'A vast circle of scarlet stars came up into the greenish desert dusk.'
Neuromorphic Computing Hardare
'He had constructed an organ, a brain, of metal, entirely inorganic and lifeless...'
Vascularized Human Skin 3D Printed
Trillionaires Still Earth-Bound
'I shall never forget the sight... when the yellow gleam of the precious metal appeared under the star dust.'
Digit V2 Bipedal Robot From Agility Robotics
Oh, and now I suppose someone will develop the robotic porch pirate.
3D Printed Dubai Building Is World's Largest
'This thing will start at one end of ...a house and build it complete to the other end, following drawings only.'
Grow Plants On Moon Or Mars!
'In contrast to the airless desolation outside, the interior of this five-acre greenhouse was the one most desirable place to be.'
California Gets Shockwave Rider-Style Avoidance Zones
'It was cheaper to pay the refugees to go without up-to-the-minute equipment.'
Microbot Interstellar von Neumann Explorers
'Evidently they have never had a planet of their own...'
Hail SmartCan! Your Trash Bin Takes Itself Out
'...a waste can twenty feet away stirred into life.'
Finally! Microsoft Surface Neo And Surface Duo Implement Excellent Courier Idea
'Runcible, whose pages were thicker and more densely packed with computational machinery...'
Tap Strap 2 Now With Air Mouse
'He waved his hand and the circuit switched abruptly.'
Legal Profession Now Fairly Bristling With AI
'The virtual counsel appeared to be about forty-five years old and prosperous.'
Entire Planet Modeled In New MS Flight Sim
'CIC uses [it] to keep track of every bit of spatial information that it owns...'
FlyZoo Robot Hotel By Alibaba
'... hotels that specialized in non-human service.'
Implanted Memories Provide Songs To Birds
Finches can't tell the difference.
More SF in the News Stories
More Beyond Technovelgy science news stories