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Mind-Altering Drugs Administered Deep Into The Brain
Duke University researchers have worked with mice, stress-susceptible animals that appeared depressed or anxious. By inserting drugs deep within the brain, the mice were restored to relatively normal behavior, according to a study appearing in the forthcoming July 20 issue of Neuron.
They then applied engineered molecules called DREADD (Designer Receptors Exclusively Activated by Designer Drug), developed by University of North Carolina at Chapel Hill pharmacologist Bryan Roth, in very tiny amounts (0.5 microliter). A drug that attaches only to that DREADD is then administered to give the researchers control over the circuit.
They found that direct stimulation of PFC-amygdala neural circuitry with DREADDs normalized PFC-dependent limbic synchrony in stress-susceptible animals and restored normal behavior.
In his 2015 novel Killing Titan, Greg Bear writes about cranial amplified programming devices and suits that can settle mood-altering chemicals deep into the brain and the body.
Via KurzweilAI.
The team started by precisely placing arrays of 32 electrodes in four brain areas of the mice (see illustration above). Then they recorded brain activity as these mice were subjected to a stressful situation called chronic social defeat.* This allowed the researchers to observe the activity between the prefrontal cortex and three areas of the limbic system that are implicated in major depression...
Hey, I'm in a good mood. I'm laughing in my big thick helm, even as painful and intrusive bits of the suit - my suit, my friend! - absorb my sweet flesh the way product eats the station. I'm down with that. I'm down with pain, poison and frozen death. Happy to serve!"
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Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
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Current News
Biohybrid Robots Made Of Living And Synthetic Materials
'If the biological robots were not living creatures, they were certainly very good imitations.'
Drug Induces Hibernation-Like State In Humans
'... drugged and chilled and stowed in sleep tanks.'
Poul Anderson's 'Brain Wave'
"Everybody and his dog, it seemed, wanted to live out in the country; transportation and communication were no longer isolating factors."
AI Note-Taking From Google Meet
'... the new typewriter that could be talked to, and which transposed the spoken sound into typed words.'
Qore IcePlates Are Personal Cooling Suits
'... underneath they consisted of networks of cooling tubes against the skin.'
P1 Just The Latest Robot To Take A Beating From Humans
'...we mere people come second.'
Waymo Cars Shout At Each Other, Autonomously
'My cars talk to one another. I have no doubt about it...'
Your Solar Electric Paint Is Ready, Larry Niven
'...you spray it on.'
How Long Till We Have These Tattoos?
Truth or fiction?
Seeing Faces On Grains Of Sand (AI Pareidolia)
'... the imprint of her image on the telephoto cell.'
Lunar Biorepository Proposed For Cryo-Preservation Of Earth Species
'...there was no one alive who had ever seen them. But they existed in the Life Bank.'
Tele-Driving Offers Jobs For Tele-Drivers, Not AIs
''...some bored drone pusher in a remote driving centre...'
Autonomous Robotic Dentist - Would You Say 'Ahhh'?
You might be surprised at how much more efficient this could be.
GM Scraps Cruise Origin Robotaxi With No Steering Wheel
'Ames tinkered around with something on the instrument board when he got in; and in a few moments we were off.'
Taza Aya Air-Curtain Tech Protects Turkey Workers
'I'm going to have to buy a filter-mask.'
Torobo Humanoid Robot Hammers A Nail
7-axis dual arms, 3-axis waist (pitch, pitch, yaw), 3-axis neck (yaw, pitch, roll), and 4-axis undercarriage!
