Mind-Altering Drugs Administered Deep Into The Brain

Duke University researchers have worked with mice, stress-susceptible animals that appeared depressed or anxious. By inserting drugs deep within the brain, the mice were restored to relatively normal behavior, according to a study appearing in the forthcoming July 20 issue of Neuron.

The team started by precisely placing arrays of 32 electrodes in four brain areas of the mice (see illustration above). Then they recorded brain activity as these mice were subjected to a stressful situation called chronic social defeat.* This allowed the researchers to observe the activity between the prefrontal cortex and three areas of the limbic system that are implicated in major depression...

They then applied engineered molecules called DREADD (Designer Receptors Exclusively Activated by Designer Drug), developed by University of North Carolina at Chapel Hill pharmacologist Bryan Roth, in very tiny amounts (0.5 microliter). A drug that attaches only to that DREADD is then administered to give the researchers control over the circuit.

They found that direct stimulation of PFC-amygdala neural circuitry with DREADDs normalized PFC-dependent limbic synchrony in stress-susceptible animals and restored normal behavior.

In his 2015 novel Killing Titan, Greg Bear writes about cranial amplified programming devices and suits that can settle mood-altering chemicals deep into the brain and the body.

Hey, I'm in a good mood. I'm laughing in my big thick helm, even as painful and intrusive bits of the suit - my suit, my friend! - absorb my sweet flesh the way product eats the station. I'm down with that. I'm down with pain, poison and frozen death. Happy to serve!"

Via KurzweilAI.

Scroll down for more stories in the same category. (Story submitted 6/22/2016)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Biotech Firms Raised $Millions For Anti-Agathics (Longevity Drugs)
'Against Death doth no simple grow.' - James Blish, 1957.

Medical Tattoos Are STILL Being Researched
'Following the current craze, she has had a subdermal pattern of micro-channels implanted.'

Rise Of Skywalker Could Trigger Epileptic Seizures
'... then the screen started to flicker. I stared at it for a while.' - John Varley, 1984.

Injectable Magnetic Fluid Slows Bleeding, Aids Magneto
'There's something different about you.'

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

PRAM Solar Powered Satellite Hardware Tested In Orbit
'Our beams feed these worlds energy drawn from... the Sun'

3D Printed Glass Uses Stereolithography Techniques
'All that with glass...'

Science Fiction Helps Young Readers Build Resiliency
'Reading science fiction and fantasy can help readers make sense of the world.'

I Want My 1928 Telestereo Hologram Now
'Instantly there appeared standing upon the disk, the image of a man...'

Memes Now Come From Neural Nets
'Your order said for him to be able to be able to work out twists on the gags in the file...'

Robot Dog Learns To Be Doggy From Real Dogs
'So we took pictures of Guzub making a Three Planets, and I could construct this one to do it exactly right down to the thousandth of a second.'

Unwanted Cruise Ships Huddle Together Out At Sea
'On the screen they passed in an endless, boundaryless flood of green specks...'

Sono Sion Electric Car Charges As You Drive
'It drew its power from six square yards of sunpower screens on its low curved roof.'

News Mood Filter Web Extension
'He adjusted the n, the r and b knobs, and hopefully anticipated a turn for the better...'

Fetal Lamb Rests In Artificial Womb
'... stewing warm on their cushion of peritoneum and gorged with blood-surrogate and hormones, the foetuses grew and grew...'

MIT Wants To Catch Interstellar Visitors
'INVESTIGATE MYSTERIOUS OBJECT ENTERING NEW CALEDONIA SYSTEM FROM NORMAL SPACE'

AutoX Sets Up Asia's Largest Robotaxi Center
'The robot cab seemed to know where it was going and, no doubt, the master machine from which it received its signals knew.'

E - Ink's Automatic Self Styling Color-Changing Dress
'The racks of gowns itched and quivered, their colors running into blurred pools.'

Soft Robots Use Kirigami Piezoelectric Sensor Skin
'A worthy opponent was the golem.'

Bosch Smartglasses Laser Paints AR Image On Your Retina
'Soon we'll be testing a system that projects directly on the retina of the eye.'

Maybe We Could Hibernate Until The Covid-19 Pandemic's End
'Cold-rest was a common last resort therapy for functional psychoses.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.