Mind-Altering Drugs Administered Deep Into The Brain

Duke University researchers have worked with mice, stress-susceptible animals that appeared depressed or anxious. By inserting drugs deep within the brain, the mice were restored to relatively normal behavior, according to a study appearing in the forthcoming July 20 issue of Neuron.

The team started by precisely placing arrays of 32 electrodes in four brain areas of the mice (see illustration above). Then they recorded brain activity as these mice were subjected to a stressful situation called chronic social defeat.* This allowed the researchers to observe the activity between the prefrontal cortex and three areas of the limbic system that are implicated in major depression...

They then applied engineered molecules called DREADD (Designer Receptors Exclusively Activated by Designer Drug), developed by University of North Carolina at Chapel Hill pharmacologist Bryan Roth, in very tiny amounts (0.5 microliter). A drug that attaches only to that DREADD is then administered to give the researchers control over the circuit.

They found that direct stimulation of PFC-amygdala neural circuitry with DREADDs normalized PFC-dependent limbic synchrony in stress-susceptible animals and restored normal behavior.

In his 2015 novel Killing Titan, Greg Bear writes about cranial amplified programming devices and suits that can settle mood-altering chemicals deep into the brain and the body.

Hey, I'm in a good mood. I'm laughing in my big thick helm, even as painful and intrusive bits of the suit - my suit, my friend! - absorb my sweet flesh the way product eats the station. I'm down with that. I'm down with pain, poison and frozen death. Happy to serve!"

Via KurzweilAI.

Scroll down for more stories in the same category. (Story submitted 6/22/2016)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.' - Frank Herbert, 1972.

EXPLORER, The First Total-Body Scanner
'The object is built up of an infinite series of plane layers, at the focus of the ray...' - Jack Williamson, 1930.

Bioreactor Helps Legless Frogs Get Their Jump Back
'An alien drug... Used by an insect race... It can repair bones and organs. It can grow new tissue." - Clifford Simak, 1961

Sleeep PRO Earplug For Maximum Rest
'Merton... placed the electrodes of the sleep-inducer on his forehead.' - Arthur C. Clarke, 1963.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.'

Flying Dragon Robot Transforms In Mid-Air
Terrific prototype video.

Negative Matter Fluid Theorized In New Paper
'Of course, being negative matter, when you push it, it comes toward you..'

Grow Structures Upon Planetfall - Myco-Architecture
'They'll also start pulling in gases and liquids from the local atmosphere...'

MXene Hydrogel Skin For Robots Flexes And Senses
'The plastex swam and whirled like boiling toothpaste...'

EXPLORER, The First Total-Body Scanner
'The object is built up of an infinite series of plane layers, at the focus of the ray...'

UK Police AI To Stop Criminals Before They Strike
'... the computing mechanisms that studied and restructured the incoming material.'

Sonitus Audio Interface Positioned Beyond The Noise
'... an instrument having relatively small bit pieces adapted to be gripped between the teeth.'

Volvo's Self-Driving Mining Trucks
'A procession of automatic ore carts was racing over the bleak slag'

Audi Pop.Up Autonomous Electric Flying Car
'The cab was an egg-shaped bubble of light metals and plastics...'

Music Not Impossible (MNI) Vibrotactile Wearable Experience
Don't you want to experience the 'feely' effects?

Chinese Face Recognition Mistakes Bus Ad For Jaywalker
'... the imprint of her image on the telephoto cell.'

A Look Back At Apollo's Emergency Escape Vehicle
'A simple mechanism... it drove the iron ball through space like a ship.'

InMotion Glide 3 Electric Unicycle For The Last Mile
'...gyro-stabilized on a single wheel.'

China's Social Credit System - A Facebook-1984 Mashup
'Prestige, face, mana, repute, glory: the Sirenese word is strakh.'

Musk Declares Tesla Supercharger Capacity Will Double By Next Year
'Recharge the batteries... in almost every town and village...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.