Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Fantastic Voyage Of Self-assembling Peptide Nanofibers
In the 1966 science fiction movie Fantastic Voyage, researchers miniaturize a delivery mechanism and inject it into a human body. In a modern day sequel, Harvard Medical School researchers have used injectable self-assembling peptide nanofibers loaded with the pro-survival factor PDGF-BB to protect rat hearts from injury and subsequent heart failure. Their study will appear in the January 2006 issue of the Journal of Clinical Investigation.
(1966 Fantastic Voyage)
Narrowed or blocked blood vessels are unable to deliver sufficient levels of oxygen to cardiomyocytes, which results in cardiomyocyte death, loss of the middle layer of the heart wall (the myocardium), and ultimately, heart failure. Therefore, therapies that protect cardiomyocytes from death may help prevent heart failure.In the current study, Richard Lee and colleagues show that PDGF-BB has a direct pro-survival effect on cardiomyocytes. The authors went on to design a strategy in which short, self-assembling peptide nanofibers bind this pro-survival growth factor and, following injection into rat myocardium, facilitated prolonged and controlled delivery of PDGF-BB to the infarcted heart for up to 14 days. This strategy protected cardiomyocytes from injury, reduced infarct size, and preserved cardiac function. This effect could not be achieved by injecting nanofibers or PDGF-BB alone.
In a previous paper, Dr. Lee and his team demonstrated that self-assembling peptide nanofibers can be injected, and that the resulting nanofiber microenvironment can be seen.
If you are interested in this topic, you might also be interested in an Artist's View Of Medical Nanorobots. Read more at ZDNet, the press release, and Molecular Cardiology. And thanks to Fred Kiesche for pointing this one out.
Scroll down for more stories in the same category. (Story submitted 12/20/2005)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Medical ")
MouthPad Supports Head And Tongue Tracking
'The operation that had transformed half his body... had located the control switchboard in his teeth.'- Alfred Bester, 1956.
Drug Induces Hibernation-Like State In Humans
'... drugged and chilled and stowed in sleep tanks.' - Robert Heinlein, 1951.
Drug To Regenerate Teeth In Humans
'We want to do something to help those who are suffering from tooth loss or absence,' said lead researcher Katsu Takahashi.
Illustrating Classic Heinlein With AI
'Stasis, cold sleep, hibernation, hypothermia, reduced metabolism, call it what you will - the logistics-medicine research teams had found a way to stack people like cordwood and use them when needed.' - Robert Heinlein, 1956
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
Mechazilla Arms Catch A Falling Starship, But Check Out SF Landing-ARMS
'...the rocket’s landing-arms automatically unfolded.'
A System To Defeat AI Face Recognition
'...points and patches of light... sliding all over their faces in a programmed manner that had been designed to foil facial recognition systems.'
Robot Hand Separate From Robot
'The crawling, exploring object was V-Stephen's surgeon-hand...'
Hybrid Wind Solar Devices
'...the combined Wind-Suncatcher, like a spray of tulips mounted fanwise.'
Is Optimus Autonomous Or Teleoperated?
'I went to the control room where the three other men were manipulating their mechanical men.'
Robot Masseuse Rubs People The Right Way
'The automatic massager began to fumble gently...'
Solar-Powered Space Trains On The Moon
'The low-slung monorail car, straddling its single track, bored through the shadows on a slowly rising course.'
Drone Deliveries Instead Of Waiters In Restaurants?
'It was a smooth ovoid floating a few inches from the floor...'
Optimus Robot Can Charge Itself
'... he thrust in his charging arm to replenish his store of energy.'
Skip Movewear Arc'teryx AI Pants
'...the terrible Jovian gravity that made each movement an effort.'
'Robovan' Name Already Taken - Elon, Try These
There are alternative names that are probably in the public domain by now.
How Old Are Tesla Designs?
You be the judge.
Is Your Autonomous Tractor Safe?
'The field-minder finished turning the top-soil of a two-thousand-acre field.'
Smart TVs Are Listening!
'You had to live -- did live, from habit that became instinct -- in the assumption that every sound you made was overheard...'
Police Drones In China Would Like To Have A Word With You
''OVERRIDE,' the City Fathers said suddenly, without being asked anything at all.'
Oh Great (Part 2), Fence-Climbing Robots
Please, no stingers.
