Science Fiction Dictionary
A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

 

Mighty Mice Now With PEPCK-Cmus!

PEPCK-Cmus "mighty mice" are transgenic mice bred at Case Western Reserve University. These mice are able to run five or six kilometers at a speed of twenty meters per minute on a treadmill.


(Mighty Mice PEPCK-Cmus Supermouse video)

The PEPCK-Cmus mice eat about sixty percent more than the control mice, but remain fitter, trimmer and live and breed longer than wild mice in a control group.

These mice achieve excellence in a manner that seems to be very similar to the way that Lance Armstrong does it - he was born with specific capacities make him different from most people. For example, when he exercises, his body utilizes lactate more efficiently; it does not accumulate as it does in most bikers and runners.

"Armstrong's most unusual attribute may be his low lactate levels. During intense training, the levels of most racers range from 12 μL/kg to as much as 20 μL/kg; Armstrong is below 6 μL/kg."

Lactate is believed to be a useful fuel for the body. And what about the "mighty mice?"

"What is particularly dramatic is the difference in the concentrations of lactate in the blood," the researchers said. "At the beginning of exercise, the concentration of lactate was similar in two groups of mice, but by the end of the exercise period, the control group had elevated levels of blood lactate with little change in the levels in the PEPCK-Cmus mice."

The technical reason for their amazing physical feats? The over-expression of the gene for the enzyme phosphoenolypyruvate carboxykinases (PEPCK-C). The "mighty mice" are descended from founder lines that had an additional gene added. It is a chimeric gene; a copy of the cDNA for PEPCK-C was linked to the skeletal actin gene promoter, containing the 3'-end of the bovine growth hormone gene. The skeletal actin gene promoter directs expression of PEPCK-C exclusively to skeletal muscle. Various lines of PEPCK-Cmus mice expressed PEPCK-C at different levels, but one very active line of PEPCK-Cmus mice had levels of PEPCK-C activity of 9 units/gram skeletal muscle, compared to only 0.08 units/gram in the muscles of control animals.

Science fiction fans are long familiar with the idea of beings who have been engineered to be superior. For example, consider the eugenic "supermen" from Star Trek.


(Khan Noonien Singh - played by Ricardo Montalban)

Fans might also recall the Sauron Supermen from Niven and Pournelle's The Mote in God's Eye.

Mice are quickly acquiring other remarkable characteristics, thanks to hard-working researchers:

  • E.T. Mouse Hearts Glow
    Researchers at Cornell have created mice whose heart muscles have been genetically engineered to fluoresce when the muscles contract (see photo).
  • Mouse With Human Brain May Live
    Stanford University has given famed researcher Irving Weissman permission to create a mouse-human hybrid.

From Case Western mighty mouse press release.

Scroll down for more stories in the same category. (Story submitted 11/2/2007)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 3 )

Related News Stories - (" Biology ")

Baubotanik - Construction Botany - Builds Bridges
'A dwelling must be all of a unit—the walls, the drainage, the decor grown in!' - Jack Vance, 1954.

Mice Gestate In Mechanical Womb
'... in the Decanting Room, the newly-unbottled babes uttered their first yell of horror and amazement.' - Aldous Huxley, 1932.

Worlds With Underground Oceans More Conducive To Life
'There is life on Europa.' - Arthur C. Clarke, 1982.

Monkey Gets A Bigger Brain, Thanks To Human Gene
'It's a madhouse! a madhouse!' - Planet of the Apes, 1968.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

Science Fiction Timeline
1600-1899
1900-1939
1940's   1950's
1960's   1970's
1980's   1990's
2000's   2010's

Current News

CyberOne Robot By Xiaomi vs. Optimus Robot By Tesla
'I shall introduce myself... I am a robot.'

Giving Snakes Their Legs Back
Then some unknown race had chanced upon the dreamers and decided to 'help them out.'

'Ring Nation' Show Predicted By William Gibson In 1999
'... you had your trademark Lucky Dragon Global Interactive Video Column outside.'

SolarXOne Solar-Powered Drone Flies (almost) Forever
'It's an Indian Air Force drone; its solar cells could power an entire farm.'

Video! Chess Robot Breaks Opponent's Finger In Match
'A robot may not injure a human being.'

Virtual Co-Embodyment - Two People Control One Virtual Body
'... we were supposed to be forming five unit composites first."

The Wanderer: Eyebot From Fallout, Eye From Zelazny
'We send our eyes on their appointed rounds, and they can hover or soar or back up...'

Experts Decry Planet-Scale Schemes To Limit Global Heating
'Light from the sun hit those little spheres and bounced.'

OrganEx Revives The Organs In Dead Pig
'Wakened into half-life activity one hour a month...'

NAVER Labs Haptic Device 2.0 Robot vs. IKEA
'... the two pairs of waldoes in the screen followed in exact, simultaneous parallelism.'

Spaceships Should Last So Long
'THE SPACE VESSEL was traveling swiftly… For over five thousand years they had Voyaged on and on.’

Shine On, Portable Wind Turbine
'Sometimes a man has a windmill on his roof...'

Amazing Indoor Robotic Drones Mimic Dolphins and Whales
'They circled the vast audiences, dancing, twittering, chirping...'

Space Station Shutters
'The sun-quilt was a patchwork of colors and materials on the inward side, but silvered on the outward side...'

Tiny Mining - Extract Precious Industrial Minerals From Your Own Body
'Jim, I saw them reduce four of my doctors and nurses into those little cubes!'

MIT Proposes Space Bubbles To Combat Climate Change, Misses The Point Of Space Bubbles
'Fats Jordan was hanging in the center of the Big Glass Balloon, hugging his guitar to his massive black belly above his purple shorts..'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.