E.T. Mouse Hearts Glow

Researchers at Cornell have created mice whose heart muscles have been genetically engineered to fluoresce when the muscles contract. Junichi Nakai of the RIKEN Brain Science Institute in Wako-shi, Japan, developed the fluorescent molecule by modifying a green fluorescent protein (derived from bioluminescent jellyfish) and making it glow brightly enough to be observed in the working heart. The sensor molecule turns on and off like a switch in the presence of calcium; calcium concentrations in the muscle increase with each muscle contraction.


(Mouse embryo heart fluoresces as it contracts with each beat)

In the graphic shown above, the heart of a mouse embryo goes from a resting state between beats (upper left) through upper heart chamber contraction, then finally lower heart chamber contraction (lower right).

Incredibly, in order to photograph a mouse heart beat (the mouse embryo's heart beats 6-10 times per second), a special camera cooled to -90 degrees Celsius is used to get a sharp image.

By the tenth day of development, a rudimentary heart is already beating, but it has only two chambers. The upper chamber contracts first, then the lower; this delay in contractions is obviously necessary for efficient pumping action. However, the atrio-ventricular node (AV node) does not develop until the thirteenth day; so, how does the heart function without it?

This technique allowed researchers to discover a layer of specialized cells on the surface of the developing heart that delays the beats between upper and lower chambers. These cells die off once the AV node has developed.


(E.T. and Elliot)

This isn't really a case in which science fiction has specifically anticipated a real scientific development, but I couldn't resist the story. In the movie E.T. the Extraterrestrial director Steven Spielberg shows E.T.'s heart glowing as he communicates with his fellows aboard their ship.

For more miraculous mice stories, read Lab Mice Unexpectedly Regenerate Limbs, Organs, Klotho Anti-Aging Mouse Gene and Yoda - The World's Oldest Mouse. Read more about mice with glowing hearts.

Scroll down for more stories in the same category. (Story submitted 3/10/2006)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 1 )

Related News Stories - (" Biology ")

Fetal Lamb Rests In Artificial Womb
'... stewing warm on their cushion of peritoneum and gorged with blood-surrogate and hormones, the foetuses grew and grew...' - Aldous Huxley, 1932.

Bring Back Extinct Animals! Sort of.
'The worldwide network of genetic arks had a surfeit of pachyderms...' - David Brin, 1990

Another Soil Bacterium Eats Plastic
'...the plastic was dissolved before his eyes.' - Michael Crichton, 1969.

Mushroom Eats Plastic, Saves Planet
Fungus Amongus, SaveUs!

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

TytoCare Offers Futuristic Home Care
'Immediately an enormous apparatus fell on to her out of the ceiling...'

Powdered Regolith Propulsion
'... filling their great tanks with the finely divided dust which the ionic rockets would spit out in electrified jets.'

Ford's SafeCap, Opposite Of Niven and Barnes' Napcap
'In the napcap a client became an instant yoga master...'

Would You Get 'Chipped'? Michigan May Ban Employers
'Employees above a certain level were implanted with advanced microprocessors...'

Tesla Autopilot: What Does An Autonomous Car See When It Looks At The Road?
'Jeremiah is a sports-model to begin with and that kind is awfully hot-tempered.'

DNA Controls Swarms Of Molecular Robots
'They exist in loose swarms...'

Tether Asteroids To Save Us All
'If anything can glue the asteroids back into the planet they once were, magnology will do it.'

Blaux Your Personal Commuter Cooling Unit
A cooling unit had to be strapped to every commuter's back, by law.

3D Printed Damascus Steel Now Possible
'...lined with durite, that strange close-packed laboratory product.'

R9X Hellfire Missile With Long Blades Kills Queda Leader
'He was still roaring when the knife missile flicked past him...'

Would You Swallow An Origami Robot?
'Swallow it in an emergency--it goes down easily and works just as well inside as outside.'

Perhaps You Might Be Interested In Habitable Exoplanet Moon Real Estate
A long time ago in a galaxy far, far away...

Blurry Face Photos Made 60 Times Sharper
Perfect tool for blade runners.

SpaceX Will Build Floating Spaceports!
'...a single perfectly level platform, which rose so high above the water that it was not splashed by the waves.'

Fast Radio Bursts And Space Beacons For Interstellar Navigation
'Every beacon has a code signal as part of its radiation...'

Robot Garbage Trucks Visualized
'It was a bulky, shining cylinder over twenty metres long.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.