Klotho Anti-Aging Gene

Klotho, a gene in both mice and men, has a definite effect on aging, according to Dr. Makoto Kuro-o. Stimulating the Klotho gene seems to delay many of the effects of old age, like weakening of bones, clogging of the arteries and loss of muscle fitness.


(From Klotho anti-aging mouse gene)

For their current study, Kuro-o and colleagues created a strain of mice in which the Klotho gene is more active than in normal mice. The mice lived between 19% and 31% longer than normal mice.

Dr. Kuro-o writes;

To understand the mechanism by which Klotho suppresses aging, my laboratory is focused on determining specific activity of Klotho protein and identifying molecules that interact with Klotho. The klotho mouse is the first laboratory animal model of human aging caused by a single gene mutation. Studies on the klotho mouse and the klotho gene are thus expected to provide new insights into human aging.

An interesting note is that it appears that the Klotho-enhanced mice who are more long-lived seem to have fewer offspring as a side effect. Also, the effect of Klotho on insulin could create a problem because it may extend life at the expense of making people diabetic.

Mice with the Klotho gene are not the first to help human beings achieve longer life; read about Yoda, the world's oldest mouse and the Methuselah Mouse 'M' Prize.

Science fiction authors have been interested in technologies that might lengthen human life; almost invariably, each of these methods also has a particular flaw. Kurt Vonnegut wrote about anti-gerasone in his well-known short story Tomorrow and Tomorrow and Tomorrow. Anti-gerasone's flaw was that it worked too well - neither material goods nore inheritance laws could keep up.

In A World Out Of Time, Larry Niven writes about a drug called young-forever, which puts off death almost forever. Unfortunately, it works only with children, who then never go through puberty.

The desire to live forever, and the belief that it will never quite work out, of course predates science fiction authors. The ancient Greeks wrote about the goddess Eos, who fell in live with a mortal man, Tithonus; she asked Zeus to grant him immortality. Zeus did so, but Eos forgot to ask for eternal youth; Tithonus lived on and on, eventually withering into a shrill grasshopper.

And, as it happens, the name "Klotho" is also derived from the Greek myths. Klotho combed and spun the thread of one's life, Atropos wove the thread into the fabric of one's actions, and Lachesis snipped the thread at death.

Find out more about Dr. Makoto Kuro-O and Anti-aging protein extends mouse lifespan.

Scroll down for more stories in the same category. (Story submitted 8/29/2005)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Medical ")

Skin Electronics Can Show Electrocardiogram
'... the young men in the streets who applied polyimde OLED body film to their bared shoulders.' - Chen Qiufan, 2019.

Neurodevices For Consumers? Neuroethicists (And Philip K Dick) Say 'Caveat Emptor'
'They tried to use it today and it wouldn't work. No colors and no ceph patterns, neither one...' - Philip K. Dick, 1977.

BrainEx Restores Some Activity To Severed Pig Head
'... they placed the brain in a special solution, having all the properties of Nursing the brain cells.' - Edmond Hamilton, 1929.

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

China Deploys Robot Traffic Police
'The robot came up smooth and fast as a rocket...'

Better Than Dune Chromoplastic? This Guy Might Have Done It
'But when Old Father Sun departs, the chromoplastic reverts to transparency in the dark.'

Gather, An AI Warehouse Inventory Drone Startup
'It extended three of its tiny arms sideways to lock onto the registration pins...'

China's Artificial Intelligence-Enhanced Education
'The grey gas not only cut off his vision, but also his other senses...'

Orbital Manufacturer 'Made in Space' Gets $73 Million NASA Contract
'Mass-produced in the orbiting factories...'

Soli Gesture Tech Will Be In Google Pixel 4
'I enjoy watching this way, but - He waved his hand and the circuit switched abruptly.'

Uber Eats Pairs Cars With Drones
Fresh grub? Let's hope they aren't delivering grubs.

Space-Based Solar Power Roundup
SF writers popularized and elaborated on this idea a generation before the first patents were filed.

Lost Language Meanings Found By Machine Learning
'The autopilot would need data before it could begin a translation...'

'Aerogel' Sheets For Martian Gardens
'Sealed to the ground along all the sides, Honey, he growled...'

France's 'Red Team' Of Science Fiction Authors
'They're the only experts we have.'

Dim The Sun With Stratospheric Controlled Perturbation Experiment
'Those twin volcanoes; d'ye see them, Mr. Renner?'

Mashambas Skyscraper Farm Design Wins
'...a towering eighty-story structure like the office In-and Out baskets stacked up to the sky.'

Self-Driving Tractors From China Plan Ahead
'Machines that seemingly with full consciousness walked out into the fields to do their daily work.'

Jet-Powered Hoverboard Works!
L'audace, l'audace, toujours l'audace!

Nobe 3-Wheel Electric Vehicle Parking Like I, Robot
Spidercar, Spidercar, does whatever a spidercar does.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.