First Methuselah Mouse Rejuvenation 'M Prize' Awarded

The first Methuselah Foundation Rejuvenation 'M Prize" for Reversing Aging in Middle-Aged Mice Using Techniques Applicable to Human Beings has been awarded to Dr. Stephen Spindler, who lead an experiment to make mice biologically younger while extending their lifespans.

The research was first reported in the Proceedings of the National Academy of science. Dr. Spindler demonstrated that middle-aged mice could achieve an average 15% longer life, accompanied by significant reductions in deaths from cancer. DNA microarray analysis showed that the mice actually became younger; this video of the elderly mice sprinting around in their cages makes its own statement. The results were achieved using calorie restriction in a group of mice starting at age 19 months.

The best news at all for those of us who cannot see imposing a calorie restriction diet on ourselves (even if caged) can take heart from this exerpt from Dr. Spindler's paper:

Importantly, these results suggest that it should be possible to use rapid treatments with pharmaceuticals and other compounds to identify agents that mimic the rapid changes in gene expression caused by caloric restriction. The gene expression biomarkers of caloric restriction can also be used to develop pharmaceuticals targeted to its genomic effects.

The Methuselah Foundation bears some striking similarities to the Ansari XPrize foundation, which recently awarded the first XPrize to SpaceShipOne.

The Methuselah Foundation is supported by individuals who are no longer willing to stand by and do nothing while the diseases of aging disable and then take their irreplaceable loved ones away. They are taking matters into their own hands and inviting others to join with them to cure and reverse aging. Among the over 100 donors and sponsors, including the X PRIZE Foundation, Foresight Institute, the Life Extension Foundation, Dr. William Haseltine -- Founder of Human Genome Sciences and Dr. Raymond Kurzweil -- noted futurist and entrepreneur.

Science fiction writers have already blazed the path when it comes to setting up foundations for longevity research. Perhaps the most famous early example is that of the Howard Families, from Robert Heinlein's 1941 novel Methuselah's Children. In the story, the Howard Foundation is started in the mid-1800's by Ira Howard, who died at 48 - of old age. He gave his life's fortune as a bequest to found an organization that would seek to lengthen the span of human life. The best way at that time was to make use of basic breeding principles to encourage marriages between people with healthy vigorous grandparents. Several hundred years (and a dozen or so generations) later, the descendants of the Howard Families typically lived to 120+ years of age.

This story has many examples of devices that have now come to pass (like the traffic control camera, a machine that searches for news based on your input like google news, and the Joy-boat junior that a private citizen can ride into orbit), so why not longevity?

If you are interested longevity research based on genetic heritage, read about Yoda - The World's Oldest Mouse. Yoda's lifespan was achieved without calorie restriction - the most common method of achieving longevity in mice and other mammals.

Read more at the Scientist Wins the First Methuselah Foundation Rejuvenation "M Prize" for Reversing Aging in Middle-Aged Mice Using Techniques Applicable to Human Beings press release. Dr. Spindler's results are summarized in this abstract.

Scroll down for more stories in the same category. (Story submitted 11/28/2004)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 3 )

Related News Stories - (" Medical ")

DxtER! Tricorder Prize Won By Final Frontier Medical Devices
We've been waiting a long time for this, Star Trek fans.

Dune Fans! Your God Emperor Is Ready
'If one held a sandtrout in the hand, smoothing it over your skin, it formed a living glove.' - Frank Herbert, 1976.

H-MEX Helpful Exoskeleton From Hyundai
'We have those new suits rigged with atomic-powered lifting gadgets...' - John W. Campbell, 1938.

3D Skin Printer Helps Burn Victims
'Over her lacerated right shoulder he sprayed art-derm...'- Philip K. Dick, 1960.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Cattle Avoidance Feature In Indian Autonomous Cars
'The driver went about the business of gently slipping the teflon-coated metal scoop beneath the first animal...'

Project KOVR Fashion Protection From Infosphere
'... the entire shroudlike membrane took on whatever physical characteristics were projected at any nanosecond.'

Twist Bioscience High Density Digital Data On DNA
'They tied the memory to the bloodline and that was their record!'

'We're Not Creating A Terminator' Say Russians About Gun-Wielding Robot Fedor
Nobody is thinking about the Terminator. Westworld, maybe.

Vantablack Now IMMEASURABLY Black
'a black coating now thatís ninety-nine percent absorptive...'

Mercedes-Benz Autonomous Taxi Fleet In 3 Years
'... the taxi utilized sophisticated electronic sensors to perceive its surroundings.'

Is 'The Pulsar Positioning System' Evidence For SETI?
'For a hyperspace jump, you need at least four beacons for an accurate fix.'

Someday, You Might Like VR Enough To Move In
'That barrier was going to melt away someday soon. The transhumanists had promised...'

Humans Use Mental Power For Turtle Slavery
Now we need to start looking for animals with fingers...

Solar-Powered Moisture Vaporator
'The atmosphere yielded its moisture with reluctance.'

DxtER! Tricorder Prize Won By Final Frontier Medical Devices
We've been waiting a long time for this, Star Trek fans.

President Trump's Wall As Otra Nation Hyperloop
'...an hollow tube must be constructed the whole distance... as to admit a four wheeled carriage...'

Pickup Lines From Artificial Intelligences
'They hate us, you know... The humans. They'll stop at nothing.'

Pooper Scooper Drone Robot Watchdog 1
'Robots pick up the garbage and junk...'

Cassie Robot Brings AT-ST Walker To Life
There's even a log test!

Hundreds Of Robot Lawnmowers Invade Texas Town
'The mower reached the edge of the lawn, clucked to itself...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.