First Methuselah Mouse Rejuvenation 'M Prize' Awarded

The first Methuselah Foundation Rejuvenation 'M Prize" for Reversing Aging in Middle-Aged Mice Using Techniques Applicable to Human Beings has been awarded to Dr. Stephen Spindler, who lead an experiment to make mice biologically younger while extending their lifespans.

The research was first reported in the Proceedings of the National Academy of science. Dr. Spindler demonstrated that middle-aged mice could achieve an average 15% longer life, accompanied by significant reductions in deaths from cancer. DNA microarray analysis showed that the mice actually became younger; this video of the elderly mice sprinting around in their cages makes its own statement. The results were achieved using calorie restriction in a group of mice starting at age 19 months.

The best news at all for those of us who cannot see imposing a calorie restriction diet on ourselves (even if caged) can take heart from this exerpt from Dr. Spindler's paper:

Importantly, these results suggest that it should be possible to use rapid treatments with pharmaceuticals and other compounds to identify agents that mimic the rapid changes in gene expression caused by caloric restriction. The gene expression biomarkers of caloric restriction can also be used to develop pharmaceuticals targeted to its genomic effects.

The Methuselah Foundation bears some striking similarities to the Ansari XPrize foundation, which recently awarded the first XPrize to SpaceShipOne.

The Methuselah Foundation is supported by individuals who are no longer willing to stand by and do nothing while the diseases of aging disable and then take their irreplaceable loved ones away. They are taking matters into their own hands and inviting others to join with them to cure and reverse aging. Among the over 100 donors and sponsors, including the X PRIZE Foundation, Foresight Institute, the Life Extension Foundation, Dr. William Haseltine -- Founder of Human Genome Sciences and Dr. Raymond Kurzweil -- noted futurist and entrepreneur.

Science fiction writers have already blazed the path when it comes to setting up foundations for longevity research. Perhaps the most famous early example is that of the Howard Families, from Robert Heinlein's 1941 novel Methuselah's Children. In the story, the Howard Foundation is started in the mid-1800's by Ira Howard, who died at 48 - of old age. He gave his life's fortune as a bequest to found an organization that would seek to lengthen the span of human life. The best way at that time was to make use of basic breeding principles to encourage marriages between people with healthy vigorous grandparents. Several hundred years (and a dozen or so generations) later, the descendants of the Howard Families typically lived to 120+ years of age.

This story has many examples of devices that have now come to pass (like the traffic control camera, a machine that searches for news based on your input like google news, and the Joy-boat junior that a private citizen can ride into orbit), so why not longevity?

If you are interested longevity research based on genetic heritage, read about Yoda - The World's Oldest Mouse. Yoda's lifespan was achieved without calorie restriction - the most common method of achieving longevity in mice and other mammals.

Read more at the Scientist Wins the First Methuselah Foundation Rejuvenation "M Prize" for Reversing Aging in Middle-Aged Mice Using Techniques Applicable to Human Beings press release. Dr. Spindler's results are summarized in this abstract.

Scroll down for more stories in the same category. (Story submitted 11/28/2004)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 3 )

Related News Stories - (" Medical ")

Surgery In Space
' It was a ... coffin, form-fitted to Nessus himself...' - Larry Niven, 1972.

Organoids Galore!
'Runciter's body contained a dozen artiforgs...'- Philip K. Dick, 1969.

Please, Please Let There Be Regenerated Teeth
'Toothbud transplants...' - William Gibson, 1984.

First Biolimb Grown In Lab
A brand-new forelimb for some lucky rat.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Robots Take Our Jobs By Reading Our Instructions
'The Talk Between Robots radio...'

Surgery In Space
' It was a ... coffin, form-fitted to Nessus himself...'

Flimmer Navy Drone Flies And Swims
Launch the Flying Sub!

Taser Drones Now Legal In North Dakota
'I sent my eyes on their rounds and tended my gallery of one hundred-thirty changing pictures...'

Growing Metal In The Shape You Want
What more do you need, engineers?

Self-Healing Materials For Spacecraft
'It even had an inter-skin layer of gum that sealed the punctures...'

World's First Full-Colour, Flexible Thin-Film Reflective Display
'A wide sheet of clear material suddenly flared with light and swirling colour....'

Jazz AI Compliments Of DARPA
'I request that you feed the correlation between those dots and the levers of the panel into my memory banks.'

Tasty Space Lettuce!
Having tested, we tasted.

See LG OLED Wallpaper - Amazing Video
'... television that unrolled like a poster.'

Canada's Inflatable Space Elevator Tower
"...establish an elevator system linking Earth to space?"

Ekso Works Industrial Exoskeleton
'Earth's scientists [devised] rigid metallic clothing not unlike armor...'

Mother Robot Evolves Her Children
'The Robot Mother... the most dangerous thing in creation.'

Cheetah 2 Robot Now Leaps Obstacles To Get You
'The legs are long, curled way up to deliver power, like a cheetah's.'

Xiaoice Will Text You And Be Your Friend
'If you spoke English, results might be whimsical...'

Synthetic Coral To Clean The Seas?
'Numberless capillaries arranged in a belt around the smart coral reef...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.