First Methuselah Mouse Rejuvenation 'M Prize' Awarded

The first Methuselah Foundation Rejuvenation 'M Prize" for Reversing Aging in Middle-Aged Mice Using Techniques Applicable to Human Beings has been awarded to Dr. Stephen Spindler, who lead an experiment to make mice biologically younger while extending their lifespans.

The research was first reported in the Proceedings of the National Academy of science. Dr. Spindler demonstrated that middle-aged mice could achieve an average 15% longer life, accompanied by significant reductions in deaths from cancer. DNA microarray analysis showed that the mice actually became younger; this video of the elderly mice sprinting around in their cages makes its own statement. The results were achieved using calorie restriction in a group of mice starting at age 19 months.

The best news at all for those of us who cannot see imposing a calorie restriction diet on ourselves (even if caged) can take heart from this exerpt from Dr. Spindler's paper:

Importantly, these results suggest that it should be possible to use rapid treatments with pharmaceuticals and other compounds to identify agents that mimic the rapid changes in gene expression caused by caloric restriction. The gene expression biomarkers of caloric restriction can also be used to develop pharmaceuticals targeted to its genomic effects.

The Methuselah Foundation bears some striking similarities to the Ansari XPrize foundation, which recently awarded the first XPrize to SpaceShipOne.

The Methuselah Foundation is supported by individuals who are no longer willing to stand by and do nothing while the diseases of aging disable and then take their irreplaceable loved ones away. They are taking matters into their own hands and inviting others to join with them to cure and reverse aging. Among the over 100 donors and sponsors, including the X PRIZE Foundation, Foresight Institute, the Life Extension Foundation, Dr. William Haseltine -- Founder of Human Genome Sciences and Dr. Raymond Kurzweil -- noted futurist and entrepreneur.

Science fiction writers have already blazed the path when it comes to setting up foundations for longevity research. Perhaps the most famous early example is that of the Howard Families, from Robert Heinlein's 1941 novel Methuselah's Children. In the story, the Howard Foundation is started in the mid-1800's by Ira Howard, who died at 48 - of old age. He gave his life's fortune as a bequest to found an organization that would seek to lengthen the span of human life. The best way at that time was to make use of basic breeding principles to encourage marriages between people with healthy vigorous grandparents. Several hundred years (and a dozen or so generations) later, the descendants of the Howard Families typically lived to 120+ years of age.

This story has many examples of devices that have now come to pass (like the traffic control camera, a machine that searches for news based on your input like google news, and the Joy-boat junior that a private citizen can ride into orbit), so why not longevity?

If you are interested longevity research based on genetic heritage, read about Yoda - The World's Oldest Mouse. Yoda's lifespan was achieved without calorie restriction - the most common method of achieving longevity in mice and other mammals.

Read more at the Scientist Wins the First Methuselah Foundation Rejuvenation "M Prize" for Reversing Aging in Middle-Aged Mice Using Techniques Applicable to Human Beings press release. Dr. Spindler's results are summarized in this abstract.

Scroll down for more stories in the same category. (Story submitted 11/28/2004)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 3 )

Related News Stories - (" Medical ")

Biotech Firms Raised $Millions For Anti-Agathics (Longevity Drugs)
'Against Death doth no simple grow.' - James Blish, 1957.

Medical Tattoos Are STILL Being Researched
'Following the current craze, she has had a subdermal pattern of micro-channels implanted.'

Rise Of Skywalker Could Trigger Epileptic Seizures
'... then the screen started to flicker. I stared at it for a while.' - John Varley, 1984.

Injectable Magnetic Fluid Slows Bleeding, Aids Magneto
'There's something different about you.'

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Cruise Autonomous Car Drives Aimlessly For An Hour
Convincing video shows progress (and limitations).

Fast Charging A Bus In 20 Seconds
'... in almost every town and village.'

Realistic Translation With The Waverly Labs Ambassador
'The speech patterns you actually hear decode the brainwave matrix which has been fed into your mind by your Babel fish.'

Biotech Firms Raised $Millions For Anti-Agathics (Longevity Drugs)
'Against Death doth no simple grow.'

Out-Of-Work Blue Collar Robots Need Your Help
'His legs relaxed with a rattle as he cut off all power below his waist... and ran his eye down the Help Wanted - Robot column...'

The Dawn Of Orbiting Manufacturing In 2020?
'It can be mass-produced only in the orbiting factories.'

Smart Contact Lenses Charges With 3D Printed Antenna
'He realized that it was not quite a clear lens.'

Segway S-Pod Fulfills Dire 1928 SciFi Prophecy
'Noiselessly, on rubber-tired wheels, they journeyed down the long aisles...'

Physicist Inspired By SciFi And Seeing Back In Time
'Here is the chronoscope... Scansion depends upon a special curved field...'

Airbnb Has AI Psychiatrist Looking At Your Facebook
'It's illegal to hold back information during a psyche test.'

NASA's Electric Motor Scooter
'...all the [lunar] prospectors took bicycles along as a matter of course'

Moving Suns To Different Galactic Neighborhoods
'...to swerve their star from its course, the globemen made use of a simple physical principle.'

Students Surveilled By School Phone Apps
Cheer up, students. '...cracking my SchoolBook had been easy.'

Massage Robot Has Soft Hands, Er, Pads
'The automatic massager began to fumble gently over my naked form.'

Medical Tattoos Are STILL Being Researched
'Following the current craze, she has had a subdermal pattern of micro-channels implanted.'

Elon Musk's Traffic Tunnel Challenge Is Boring
'The car vibrated... threading the maze of local tubes.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.