Rapamycin Can Repair Specific Learning Deficits

Rapamycin, a drug approved by the FDA to stop tissue rejection after organ transplants, has been found to reverse the brain dysfunction caused by a genetic disease - tuberous sclerosis complex (TSC).

"This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," explained principal investigator Dr. Alcino Silva, professor of neurobiology and psychiatry at the David Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."

"These findings challenge the theory that abnormal brain development is to blame for mental impairment in tuberous sclerosis," added first author Dan Ehninger, postgraduate researcher in neurobiology. "Our research shows that the disease's learning problems are caused by reversible changes in brain function -- not by permanent damage to the developing brain."

TSC often causes severe mental retardation; half of all TSC patients also suffer from autism and epilepsy. The disorder afflicts about one in 6,000 people - twice as common as Huntington's or Lou Gehrig's disease.

Silva and Ehninger studied mice bred with TSC and verified that the animals suffered from the same severe learning difficulties as human patients. Next, the UCLA team traced the source of the learning problems to biochemical changes sparking abnormal function of the hippocampus, a brain structure that plays a key role in memory. "Memory is as much about discarding trivial details as it is about storing useful information," said Silva, a member of the UCLA Department of Psychology and UCLA Brain Research Institute. "Our findings suggest that mice with the mutation cannot distinguish between important and unimportant data. We suspect that their brains are filled with meaningless noise that interferes with learning."

"After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said Ehninger. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories properly."

Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.


(Flowers For Algeron - a book cover you may remember)

Via EurekAlert!; thanks to Moira for the tip and the reference.

Scroll down for more stories in the same category. (Story submitted 7/16/2008)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Medical ")

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...' - Larry Niven, 1968.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.' - Frank Herbert, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

'Metallic Wood' Strong Like Titanium, Floats In Water
'A metal... light as cork and stronger than steel...'

Seabreacher, H.G. Winter's 1939 Torpoon
'Ken lay full-length in the padded body compartment, his feet resting on the controlling bars of the directional planes, hands on the torpoon's engine levers.'

Abundant Robotics Autonomous Apple Harvester Robot
'... little machines, that went from plant to plant... cutting off the ripe fruit.'

Charging An Electric Car In 2019 (Video), 1912 (Photo) And 1894 (Fiction)
'Recharge the batteries... in almost every town and village...'

Japan Uses Explosives On Asteroid
'...a tiny, rocket-powered projectile, drove towards the mysterious bulk. It hit, exploding into a cloud of incandescent vapour.'

Get Your Speeder Flying Motorcycle From Jetpack Aviation
'The flycycles were miracles of compact design.'

FLIR Black Hornet 3 Palm-sized Drone
These drones can provide situational awareness beyond visual line-of-sight capability.

Dockworkers Protest Driverless Trucks
'It resembled conventional human-operated transportation vehicles, but with one exception -- there was no driver's cabin.'

Flying Car Concept By Kash Sirinanda
'Each one consists of a hub with many tiny spokes... On the end is a squat foot, rubber tread on the bottom...'

Unfurl The Future! Huawei Mate X versus Galaxy Fold
'A paper thin polycarbon screen unfurled silently from the top of the unit and immediately grew rigid.'

Amazon Echo And Google Home Should Have Morality Software
'The Dwoskin Morality Rating-Computer could 'spot the slightest tendency to deviation' from the social norm...'

China Building Robot Wives
'Want a life-companion, a pleasant one?'

China Social Credit System Like State-Run Whuffie
'At least there was no mandatory Whuffie check on the monorail platform...'

Project Soli Radar Gesture Chip Now FCC Approved
'He waved his hand and the circuit switched abruptly.'

Stan, Robot Valet, Will Drag Your Car Away
'He activated the grapple tracks. '

Jibo Home Robot Says Goodbye, Is Killswitched
'It resembles an oyster....'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.