Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Rapamycin Can Repair Specific Learning Deficits
Rapamycin, a drug approved by the FDA to stop tissue rejection after organ transplants, has been found to reverse the brain dysfunction caused by a genetic disease - tuberous sclerosis complex (TSC).
"These findings challenge the theory that abnormal brain development is to blame for mental impairment in tuberous sclerosis," added first author Dan Ehninger, postgraduate researcher in neurobiology. "Our research shows that the disease's learning problems are caused by reversible changes in brain function -- not by permanent damage to the developing brain."
TSC often causes severe mental retardation; half of all TSC patients also suffer from autism and epilepsy. The disorder afflicts about one in 6,000 people - twice as common as Huntington's or Lou Gehrig's disease.
"After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said Ehninger. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories properly."
Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.
"This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," explained principal investigator Dr. Alcino Silva, professor of neurobiology and psychiatry at the David Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."
Silva and Ehninger studied mice bred with TSC and verified that the animals suffered from the same severe learning difficulties as human patients. Next, the UCLA team traced the source of the learning problems to biochemical changes sparking abnormal function of the hippocampus, a brain structure that plays a key role in memory.
"Memory is as much about discarding trivial details as it is about storing useful information," said Silva, a member of the UCLA Department of Psychology and UCLA Brain Research Institute. "Our findings suggest that mice with the mutation cannot distinguish between important and unimportant data. We suspect that their brains are filled with meaningless noise that interferes with learning."
(Flowers For Algeron - a book cover you may remember)
Via EurekAlert!; thanks to Moira for the tip and the reference.
Scroll down for more stories in the same category. (Story submitted 7/16/2008)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 2 )
Related News Stories - (" Medical ")
ErythroMer Artificial Blood
'My chemists are all working on the preparation of the artificial blood.' - Dr. David H. Keller, M.D.
MouthPad Supports Head And Tongue Tracking
'The operation that had transformed half his body... had located the control switchboard in his teeth.'- Alfred Bester, 1956.
Drug Induces Hibernation-Like State In Humans
'... drugged and chilled and stowed in sleep tanks.' - Robert Heinlein, 1951.
Drug To Regenerate Teeth In Humans
'We want to do something to help those who are suffering from tooth loss or absence,' said lead researcher Katsu Takahashi.
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
Tiny Flying Robot Weighs Just One Gram
'Aerostat meant anything that hung in the air. This was an easy trick to pull off nowadays.'
Some Ringworld Configurations Are Stable
'The Ringworld had no horizon. There was no line where the land curved away from the sky.'
TRANSFORM Dynamic Furniture Concept Becomes What You Need
'An adjustment panel outside the door would cause it to extrude various appurtenances in memory plastic...'
Harvard Metamaterials Change Structure Instantly
'Annealed in any shape for a time, and codified, the structure of that shape is retained down to the molecules.'
SnapBot Robots - You Choose Their Legs And They Choose Their Gaits
It's not really polite to tear the limbs off robots.
Dino From Magical Toys An AI Companion To Children
'...the imaginary companions discovered by needful children.'
Humanoid Robots Building Humanoid Robots
''Pardon me, Struthers,' he broke in suddenly... 'haven't you a section of the factory where only robot labor is employed?''
Darpa 'Defiant' Unmanned Autonomous Ship
'There was no wheel, and no steersman!'
What's The Best Way To Ship And Unpack Humanoid Robots?
'I opened the oblong box, where lay the automatons side by side...'
DNA Printed Book By Isaac Asimov Now Available
'They tied the memory to the bloodline and that was their record!'
AI Computer Chip Designs Passeth Human Understanding
'It seems that at one time computers were designed directly by human beings.'
Space Traffic Management (STM) Needed Now
'...the spot was a lonely one in an uncharted region, far from the normal lanes of space traffic.'
Fine-Tune Your Infinite Book The Way You Want It
'I squatted down beside the roller and tried to make some sense out of the knobs. There were thirty-nine of them...'
SpiRobs Soft Spiral Robotic Arm
'Beware the long, flexible, glittering tentacles...'
Holland Factory 3D Printing 500 Tons Of Steak Per Month
'...I don’t understand technical things — tell me, does it ever feel anything?"
Stratospheric Solar Geoengineering From Harvard
'Pina2bo would have to operate full blast for many years to put as much SO2 into the stratosphere as its namesake had done in a few minutes.'
