AICAR Exercise In A Pill

AICAR is exercise in a pill for mice; the drug appears to give the couch potato mouse much more stamina.


(Ronald Evans shows vial of exercise in a pill)

The drug appeared to change the physical composition of muscle, essentially transforming the tissue from sugar-burning fast-twitch fibers to fat-burning slow-twitch ones, the same change that occurs in distance runners and cyclists through training, according to research released Thursday.

"You're getting the benefits of exercise without having to do any work," said David Mangelsdorf, a pharmacologist at University of Texas Southwestern Medical Center in Dallas, who was not connected with the research.

Ronald Evans, the lead researcher and a molecular physiologist at the Salk Institute in La Jolla, has been contacted by many athletes in spite of the fact that AICAR does not appear to work in humans at the kinds of doses that mice receive. Evans has already turned over detection protocols to the World Anti-Doping Agency in Montreal just in case.

When sedentary mice were fed the drug daily for four weeks, they were able to run an average of 1,795 feet on a treadmill, 44% farther than mice that had received a placebo.

Mice seem to get all of the great science for strength and stamina; see transgenic mice for details.

Update 05-Aug-2008: As BajaB points out, the Han in Philip Nowlan's Armageddon 2419 A.D. had figured out how to do this:

Yet in spite of the fact that they had to bear their own full weight at all times, they were physically far inferior to the Americans. They lived lives of physical inertia, having machinery of every description for the performance of all labor, and convenient conveyances for any movement of more than a few steps.

Even from the twisted wreckage of this ship I could see that seats, chairs and couches played an extremely important part in their scheme of existence.

But none of the bodies were overweight. They seemed have been the bodies of men in good health, but muscularly much underdeveloped. Wilma explained to me that they had mastered the science of gland control, and of course dietetics, to the point where men and women among them not uncommonly reached the age of a hundred years with arteries and general health in splendid condition.

End update.

From AICAR: Scientists say they've put exercise in a pill; thanks to Moira for the tip on this story, and of course BajaB for the pointer to the reference.

Scroll down for more stories in the same category. (Story submitted 8/2/2008)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Medical ")

BrainEx Restores Some Activity To Severed Pig Head
'... they placed the brain in a special solution, having all the properties of Nursing the brain cells.' - Edmond Hamilton, 1929.

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...' - Larry Niven, 1968.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

BrainEx Restores Some Activity To Severed Pig Head
'... they placed the brain in a special solution, having all the properties of Nursing the brain cells.'

Yes, But Do Astrobees Have Lasers For Lightsaber Training?
'... Ancient weapons are no match for a good blaster at your side, kid.'

'Young Razorbacks Before Their Katanas Grow In'
'Twin robotic arms with gleaming three-foot sword blades unfolded from the forward hydraulic assemblies...'

A New Way To Run Into Things
'He made an adjustment, pointed the tube at the wall beside Etzwane, and projected a cone of light.'

'Metallic Wood' Strong Like Titanium, Floats In Water
'A metal... light as cork and stronger than steel...'

Seabreacher, H.G. Winter's 1939 Torpoon
'Ken lay full-length in the padded body compartment, his feet resting on the controlling bars of the directional planes, hands on the torpoon's engine levers.'

Abundant Robotics Autonomous Apple Harvester Robot
'... little machines, that went from plant to plant... cutting off the ripe fruit.'

Charging An Electric Car In 2019 (Video), 1912 (Photo) And 1894 (Fiction)
'Recharge the batteries... in almost every town and village...'

Japan Uses Explosives On Asteroid
'...a tiny, rocket-powered projectile, drove towards the mysterious bulk. It hit, exploding into a cloud of incandescent vapour.'

Get Your Speeder Flying Motorcycle From Jetpack Aviation
'The flycycles were miracles of compact design.'

FLIR Black Hornet 3 Palm-sized Drone
These drones can provide situational awareness beyond visual line-of-sight capability.

Dockworkers Protest Driverless Trucks
'It resembled conventional human-operated transportation vehicles, but with one exception -- there was no driver's cabin.'

Flying Car Concept By Kash Sirinanda
'Each one consists of a hub with many tiny spokes... On the end is a squat foot, rubber tread on the bottom...'

Unfurl The Future! Huawei Mate X versus Galaxy Fold
'A paper thin polycarbon screen unfurled silently from the top of the unit and immediately grew rigid.'

Amazon Echo And Google Home Should Have Morality Software
'The Dwoskin Morality Rating-Computer could 'spot the slightest tendency to deviation' from the social norm...'

China Building Robot Wives
'Want a life-companion, a pleasant one?'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.