PKR-Inhibiting Drugs May Boost Memory
Suppression of the molecule PKR (the double-stranded RNA-activated protein kinase) may help in the formation of long-term memory in the brain, according to researchers at the Baylor College of Medicine.
Suppression of the PKR molecule
in mutant mice (right) enhances learning
and memory by lowering GABA release,
compared to the process in "wild type"
(normal) mice (left))
"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain.
The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "We found that when we genetically inhibit PKR, we increased the excitability of brain cells and enhanced learning and memory, in a variety of behavioral tests," he said. For instance, when the authors assessed spatial memory (the memory for people, places and events) through a test in which mice use visual cues for finding a hidden platform in a circular pool, they found that normal mice had to repeat the task multiple times over many days in order to remember the platform’s location. By contrast, mice lacking PKR learned the task after only one training session.
Another key finding made by Costa-Mattioli and his team of researchers was the fact that this process could be mimicked by a PKR inhibitor - a small molecule that blocks PKR activity and thus acts as a "memory-enhancing drug."
"It is indeed quite amazing that we can also enhance both memory and brain activity with a drug that specifically targets PKR". Definitely then, the next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.
SF fans have long memories on this topic. In his 1985 story Stone Lives, Paul Di Filippo wrote about a drug called mnemotropin:
One day Stone notices a pill on his lunch tray. He asks June its nature.
"It's a mnemotropin - promotes the coding of long-term memories," she replies. "I thought it might help you..."
(Read more about mnemotropin)
From Baylor College of Medicine via Kurzweil AI.
Scroll down for more stories in the same category. (Story submitted 12/18/2011)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.
Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.
Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.
Researchers Create Bowls, Coils, Ripples Of Living Tissue
'... biological robots were not living creatures.' - Arthur C. Clarke, 1972.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Las Vegas Humans Ready To Strike Over Robots
'A worker replaced by a nubot... had to be compensated.'
You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.'
Elon Musk Seeks To Create 1941 Heinlein Speedster
'The car surged and lifted, clearing its top by a negligible margin.'
Somnox Sleep Robot - Your Sleepytime Cuddlebot
Science fiction authors are serious about sleep, too.
Real-Life Macau or Ghost In The Shell
Art imitates life imitates art.
Has Climate Change Already Been Solved By Aliens?
'I had explained," said Nessus, "that our civilisation was dying in its own waste heat.'
First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.
VirtualHome: Teaching Robots To Do Chores Around The House
'Just what did I want Flexible Frank to do? - any work a human being does around a house.'
Messaging Extraterrestrial Intelligence (METI) Workshop
SF writers have thought about this since the 19th century.
Nanorobots Roam Your Bloodstream, Cleaning It
Too bad they won't have lasers, though...
Galini 3D Printed Sleeping Pod Tiny Houses
'The houses are prefabricated units...'
MIT Boffins Create Psychopath AI On Purpose
There's a lesson in this for neural net AI engineers everywhere.
Skin Electronics 3D Printed
'June's body is a tracery of lambent lines, like some arcane capillary circuitry...'
Artificial Sensory Neurons For Prosthetics, Robots
Great for humans and robots!
China Uses Artificial Intelligence To Grade Student Papers
Looks like the City Fathers are starting to take over China's education system.
Electronic Tongues Will Rule The Kitchen
'Install taste buds in the end of one tentacle...'
More SF in the News Stories
More Beyond Technovelgy science news stories