PKR-Inhibiting Drugs May Boost Memory

Suppression of the molecule PKR (the double-stranded RNA-activated protein kinase) may help in the formation of long-term memory in the brain, according to researchers at the Baylor College of Medicine.


( Suppression of the PKR molecule
in mutant mice (right) enhances learning
and memory by lowering GABA release,
compared to the process in "wild type"
(normal) mice (left))

"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain.

The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "We found that when we genetically inhibit PKR, we increased the excitability of brain cells and enhanced learning and memory, in a variety of behavioral tests," he said. For instance, when the authors assessed spatial memory (the memory for people, places and events) through a test in which mice use visual cues for finding a hidden platform in a circular pool, they found that normal mice had to repeat the task multiple times over many days in order to remember the platform’s location. By contrast, mice lacking PKR learned the task after only one training session.

Another key finding made by Costa-Mattioli and his team of researchers was the fact that this process could be mimicked by a PKR inhibitor - a small molecule that blocks PKR activity and thus acts as a "memory-enhancing drug."

"It is indeed quite amazing that we can also enhance both memory and brain activity with a drug that specifically targets PKR". Definitely then, the next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.

SF fans have long memories on this topic. In his 1985 story Stone Lives, Paul Di Filippo wrote about a drug called mnemotropin:

One day Stone notices a pill on his lunch tray. He asks June its nature.

"It's a mnemotropin - promotes the coding of long-term memories," she replies. "I thought it might help you..."
(Read more about mnemotropin)

From Baylor College of Medicine via Kurzweil AI.

Scroll down for more stories in the same category. (Story submitted 12/18/2011)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Biology ")

Researchers Say 'Biohybrid Robot' - Clarke Said 'Biot'
'... The biological robots were not living creatures.' - Arthur C. Clarke, 1972.

Unique DNA To Foil Parts Counterfeiters
'... the only molecule, a unique protein amino acid, which could not be duplicated.' - Philip K. Dick, 1965.

Steerable Locusts Detect Explosives
Science fiction writers again provide a blueprint for the future.

Real Leather Without Cows Modern Meadow Biofabrication
'Plastissue, as any fool can see...' - WF Wallace, 1952,

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

PassivDom 3D Printed House - What If You Could Live Anywhere?
'The houses are prefabricated units...'

Breakthrough In Manufacture Of Red Blood Cells
This blood's for you!

Caihong Solar-Powered Drone 'Atmospheric Satellite'
'... placed in the wings of a plane to generate power from the light falling on that surface.'

NASA Wants Low Earth Orbit Wifi
'This was the center of Interplanetary Communications.'

Is Genetic Testing At Businesses A Bad Idea?
It's not a topic that fares well in science fiction movies-

Wearable Smart Jacket
He pressed the button in his sleeve communicator and snapped: 'Action stations!'

Store One Bit On One Atom
'...each individual molecule has a meaning.'

Fluorescent Bacteria Fashion
'The racks of gowns itched and quivered, their colors running into blurred pools.'

Keith Laumer's Bolo Autonomous Tanks Right On Schedule
'I cannot lie idle under attack.'

When Computers Develop Their Own Language, Will They Talk To Us?
'The curious absent look of a robot talking on the TBR circuits - the Talk Between Robots radio...'

LipNet Reads Lips - Until Disconnected, That Is
'We'd have to cut his higher brain functions... I'm not sure what [HAL} would think about that.'

Eterni.me - To Skype With The Dead
'Nothing... left of Jeserac but a galaxy of electrons frozen in the heart of a crystal.'

Wearable MRI Is Former Occulus/Facebook Exec's New Project
'Your cephalochromoscope... that you always turn on and play when you get home...'

Ford Stratasys Infinte Build 3D Printer
'He proudly indicated his Buick... Almost as good as the original it was printed from...'

The Space Suit As Personal Spaceship
'Darn clever, these suits...'

Dune Fans! Your God Emperor Is Ready
'If one held a sandtrout in the hand, smoothing it over your skin, it formed a living glove.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.