Super-Resolution Microscopy Provides '4D' Views
Super-resolution microscopy is a Nobel prize-winning technique that can “see” beyond Abbe’s diffraction-of-light limit, providing unprecedented views of cells and their interior structures and organelles.
But super-resolution microscopy only offers improved spatial resolution; to visualize and understand how living cells function in health and disease, high “temporal” (time) resolution is also required.
A team led by Professor Theo Lasser, head of the LOB, has developed a “4D microscope” that they dubbed PRISM (Phase Retrieval Instrument with Super-resolution Microscopy). A simple add-on to existing widefield microscopes, it combines 3D super-resolution microscopy (for high spatial resolution) with fast 3D phase (time) imaging in a single instrument. Phase imaging translates phase changes (changes over time) of light — caused by changes in cells and their organelles — into conventional spatial maps of the cells.
To achieve fast 3D phase imaging, the scientists designed an image-splitting prism that allows for simultaneous recording of a stack of eight z-displaced (at different depths) images. This allows the microscope to perform high-speed, 3D phase imaging across a volume of 2.5 x 50 x 50 micrometers. The team was able to image intracellular dynamics at up to 200 Hz (200 times per second — about six faster than conventional video cameras — allowing for imaging fast-changing events).
Science fiction fans of the 1970's loved James Hogan's 1977 novel Inherit the Stars, and in particular the idea of a trimagnescope that could provide detailed views inside any object.
Scroll down for more stories in the same category. (Story submitted 4/3/2018)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
Prufrock The Newest Boring Machine
'It sounds to me as though you had invented a kind of metal earthworm...'
Stratuscent Electronic Nose
'It's picking up diphenyl compounds and tetra hydrocarbons.' - Michael Crichton, 1985.
Smart Contact Lenses Charges With 3D Printed Antenna
'He realized that it was not quite a clear lens.' - Vernor Vinge, 2001.
Physicist Inspired By SciFi And Seeing Back In Time
'Here is the chronoscope... Scansion depends upon a special curved field...'
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Another Soil Bacterium Eats Plastic
'...the plastic was dissolved before his eyes.'
reLive Memorial Come Back As A Tree
'It was time - time to go again. She touched the leaf. She was wanted.'
Engineered Living Building Materials
'... it was the cheapest building material known.'
Draw Circuits With Conductive Ink
'It's rewiring things... squeezing silver toothpaste in a ribbon along the printed circuitry.'
Arkangel: Automatic Visual Censoring
It's whatever the Party says it is, Winston.
NASA Competition To Design A Bucket Drum For Moon Mining
'There was a heap of discarded ore where Grantline had carted and dumped it...'
Medical Assistant Robot May Roam The Halls Of Hospitals
'Take care, sir.'
No Autonomous Trucks? Wait, What?
'...it resembled conventional human-operated transportation vehicles, but with one exception -- there was no driver's cabin.'
As Big As A Biltong - World's Largest 3D Printer
'Huge and old, it squatted in the center of the settlement park... On the concrete platform... lay a heap of originals to be duplicated.'
Drones Used To Smuggle Contraband Into Prison
'And some mega chip inside so it never runs into anything and no cop ever sees it.'
Are You Ready For Commercial Space Travel?
'It wasn't a pleasant trip; it was a miserable trip on a miserable, undersized tourist rocket...'
Amplified Nerves Lead To Mind-Controlled Prosthetic Hands
'The electrical impulses generated by your brain command everything...'
FlyCroTug Micro Drones Do Heavy Lifting
'It extended three of its tiny arms sideways to lock on...'
Virtual Whitney Houston In Concert
Robot Teaches Itself To Walk
'My whole idea is to get away from a machine with a set of prearranged instructions, and let them teach themselves by trial and error.'
DARPA's Subterranean Challenge
Let the machines explore the underground city!
More SF in the News Stories
More Beyond Technovelgy science news stories