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Neural Net Discovers Antibiotic
A deep neural net algorithm discovered a new antibiotic that displays bactericidal activity against a wide phylogenetic spectrum of pathogens.
(Machine Learning in Antibiotic Discovery)
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity.We performed predictions on multiple chemical libraries and discovered a molecule from the Drug Repurposing Hub—halicin—that is structurally divergent from conventional antibiotics and displays bactericidal activity against a wide phylogenetic spectrum of pathogens including Mycobacterium tuberculosis and carbapenem-resistant Enterobacteriaceae. Halicin also effectively treated Clostridioides difficile and pan-resistant Acinetobacter baumannii infections in murine models.
Additionally, from a discrete set of 23 empirically tested predictions from >107 million molecules curated from the ZINC15 database, our model identified eight antibacterial compounds that are structurally distant from known antibiotics. This work highlights the utility of deep learning approaches to expand our antibiotic arsenal through the discovery of structurally distinct antibacterial molecules.
As far as I know, the earliest mention of a computer able to generate new science is the Total Environmental and Mental Simulator from John M. Faucette's 1968 novel Crown of Infinity.
...A computer that could simulate or duplicate the mental processes of any actual or artificial being, and through simulated total environmental stimuli create a situation of maximum stress upon that entity... No matter how much in intelligence potential Master or ally had, the TEMS always came up with a simulated being that was superior...... instantly the TEMS was creating and destroying entire systems of logic and mathematics, creating and discarding scores of new sciences.
Via A Deep Learning Approach to Antibiotic Discovery by Jonathan M. Stokes, Kevin Yang, Kyle Swanson, Tommi S. Jaakkola, Regina Barzilay and James J. Collins .
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Brin's 1990 Novel Earth Still Full Of Predictions
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'Whisper Mode' ala Blue Thunder Researched At Bristol
'Forest Lawn.'
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'But the stars are only atoms in larger space, and in that larger space the star-atoms could combine to form living matter, thinking matter, couldn't they?'
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'...to build up a video picture would require, say, ten million decisions every second. Mike, you're so fast I can't even think about it. But you aren't that fast.'
Splendid View Of Eclipse From Orbit Visualized And Repurposed By Arthur C. Clarke
'The area affected was five hundred kilometres across, and perfectly circular.'
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'Call 'em Winter Mute," said the other, making it two words.'
Goldene - A Two-Dimensional Sheet Of Gold One Atom Thick
'Hasan always pitched a Gauzy - a one-molecule-layer tent, opaque, feather-light, and very tough.'
SpaceX Wants A Moonbase Alpha
'And he had been sent with troops, supplies and bombs to command Russia's most trusted post, the Moonbase.'
Vast Apartment Living Will Get Even More Vast
'What is your population', I asked. 'About eighty millions.'
NASA Wants Self-Driving Or Remote-Controlled Vehicles For Lunar Astronauts
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Now that's power walking that Hugo Gernsback would have approved.
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'It was disturbing to think of the Flatline as a construct...'
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'...he rewired the delivery robot so that it would serve him midnight snacks.'
Electric Catamaran 'Explorer Eco 40m' Has 'Solar Skin'
'On went the electric-yacht faster and still faster.'
Orbital Mechanics, The Liftoff, The Turnover, The Retrograde Burn
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