Neural Net Discovers Antibiotic
A deep neural net algorithm discovered a new antibiotic that displays bactericidal activity against a wide phylogenetic spectrum of pathogens.
(Machine Learning in Antibiotic Discovery)
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity.
We performed predictions on multiple chemical libraries and discovered a molecule from the Drug Repurposing Hub—halicin—that is structurally divergent from conventional antibiotics and displays bactericidal activity against a wide phylogenetic spectrum of pathogens including Mycobacterium tuberculosis and carbapenem-resistant Enterobacteriaceae. Halicin also effectively treated Clostridioides difficile and pan-resistant Acinetobacter baumannii infections in murine models.
Additionally, from a discrete set of 23 empirically tested predictions from >107 million molecules curated from the ZINC15 database, our model identified eight antibacterial compounds that are structurally distant from known antibiotics. This work highlights the utility of deep learning approaches to expand our antibiotic arsenal through the discovery of structurally distinct antibacterial molecules.
As far as I know, the earliest mention of a computer able to generate new science is the Total Environmental and Mental Simulator from John M. Faucette's 1968 novel Crown of Infinity.
...A computer that could simulate or duplicate the mental processes of any actual or artificial being, and through simulated total environmental stimuli create a situation of maximum stress upon that entity... No matter how much in intelligence potential Master or ally had, the TEMS always came up with a simulated being that was superior...
... instantly the TEMS was creating and destroying entire systems of logic and mathematics, creating and discarding scores of new sciences.
Via A Deep Learning Approach to Antibiotic Discovery
by Jonathan M. Stokes, Kevin Yang, Kyle Swanson, Tommi S. Jaakkola, Regina Barzilay and James J. Collins .
Scroll down for more stories in the same category. (Story submitted 2/5/2020)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
A.I. Jesus Proclaims Machine Gospel
'... he crossed the waiting room to the Padre booth; inside he put a dime into the slot and dialed at random.' - Philip K. Dick, 1969.
Tesla Autopilot: What Does An Autonomous Car See When It Looks At The Road?
'Jeremiah is a sports-model to begin with and that kind is awfully hot-tempered.' - Isaac Asimov, 1953.
Blurry Face Photos Made 60 Times Sharper
Perfect tool for blade runners.
Clarke Was Right, Artificial Intelligences DO Dream
'Of course you will dream. No one knows why." - Arthur C. Clarke, 1984.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Tesla Will Have Metal Gear Snake Autocoupler, Musk Confirms
'Its motion was so swift, complex, and perfect that at first I did not see it as a machine, in spite of its metallic glitter.'
Starlink Satellites Leading Edge On-Orbit Debris Mitigation
Propulsion-assisted orbital decay, brought to you by SpaceX.
Healight Ultraviolet Endotracheal Device Has Covid-19 Treatment Potential
'He applied the tip of the instrument to the interior of the wound...'
Parents Use AI To See One Last Message From Their Deceased Son
'...what's to keep me from showing face, Man?'
Satoshi Tomizu Creates Pocket Universes And Worldcraft Bubbles In Glass
'The Worldcraft bubble glittered, catching the light...'
Space Hero Inc. Offers Trip To ISS As Reality Show Prize
'This is Elmer Schmitz, presenting to you the finalists in our Aviation Quiz Program...'
I Love Ceiling-Mounted Robots
'Immediately an enormous apparatus fell on to her out of the ceiling...'
Armano Remote Control Excavator
'The bulldozer moved through the... mine... '
OK, NASA 3D Printer Of Food Not Yet Star Trek Food Synthesizer
Maybe not, but we're seeing definite progress.
Kelly Clarkson Show Like Black Mirror '15 Million Merits'
'These people are pieces of software called avatars.'
Salto Jumping Robot Now Sticks Landing!
'Lucky touched the leap knob and the hopper's leg retracted.'
Gyroscopic Median-Straddling Mass Transit Vehicles
'It was among these leviathans that the little gyrocar was daring to thrust its puny self...'
Bigrating Laser Beam-Riding Light Sail Is Self-Correcting
'That sail will be twenty thousand miles at the wide part.'
ISS Astronauts Test Estee Lauder 'Advanced Night Repair' Skin Serum
'Out in the New Moon, just ask for what you want...'
LG Wing Twisting Smartphone Might Be Fun
'A polycarbon screen unfurled...'
Mushroom Coffin Returns You To Nature, Naturally
'She touched the leaf. She was wanted.'
More SF in the News Stories
More Beyond Technovelgy science news stories