The Secret of Longevity?
Apparently, genes, according to scientists at Stanford University and the University of Bologna.
Genetic studies so far have only identified a single gene (APOE, known to be involved in Alzheimer’s disease) that is different in centenarians versus normal agers.
To find the additional longevity genes, the authors first developed a new statistical method called informed GWAS (genome-wide association studies), which uses knowledge from 14 diseases to narrow down the search genes associated with longevity.
Using iGWAS, the scientists found eight SNPs (single nucleotide polymorphisms — molecular variations at different locations on the gene) that are significant for the centenarians they studied, and they were able to validate four of these in replication studies of long-lived subjects.
The four “longevity loci” (gene locations) along with the APOE gene may provide clues about physiological mechanisms for successful aging. These loci are known to be involved in various processes including cell senescence, autoimmunity, and cell signaling, and also with Alzheimer’s disease.
Future work may lead to a better understanding of how these genes promote successful aging and could identify additional longevity genes by recruiting more centenarians for analysis.
Robert Heinlein came to pretty much the same conclusion in his 1941 classic Methuselah's Children, in which he introduces his Howard Families, the long-lived.
"The first offspring resulting from unions assisted by the Howard Foundation were born in 1875.
They aroused no comment, for they were in no way remarkable. The Foundation was an openlychartered
On March 17, 1874, Ira Johnson, medical student, sat in the law offices of Deems, Wingate, Alden,
& Deems and listened to an unusual proposition. At last he interrupted the senior partner. "Just a
moment! Do I understand that you are trying to hire me to marry one of these women?"
The lawyer looked shocked. "Please, Mr. Johnson. Not at all"
"Well, it certainly sounded like it."
"No, no, such a contract would be void, against public policy. We are simply informing you, as
administrators of a trust, that should it come about that you do marry one of the young ladies on this list
it would then be our pleasant duty to endow each child of such a union according to the scale here set
forth. But there would be no Contract with us involved, nor is there any 'proposition' being made to youand
we certainly do not urge any course of action on you. We are simply informing you of certain facts."
Ira Johnson scowled and shuffled his feet. "What's it all about? Why?"
"That is the business of the Foundation. One might put it that we approve of your grandparents."
"Have you discussed me with them?" Johnson said sharply.
He felt no affection for his grandparents. A tight-fisted foursome-if any one of them had had the
grace to die at a reasonable age he would not now be worried about money enough to finish medical
Scroll down for more stories in the same category. (Story submitted 12/21/2015)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
Sleeep PRO Earplug For Maximum Rest
'Merton... placed the electrodes of the sleep-inducer on his forehead.' - Arthur C. Clarke, 1963.
You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.' - Frank Herbert, 1972.
First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.
Nanorobots Roam Your Bloodstream, Cleaning It
Too bad they won't have lasers, though...
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Jaguar I-Pace Audible Vehicle Alert System For EVs
'Of course not a vehicle moved by means of internal explosions of a derivative of rock oil...'
Autonomous 'Fiberbots' Weave Large Structures
'It extrudes material like a spider.'
Birds Aren't Real - Wake Up, California! (With Bird Watching Guide)
'When he had first built them, they had been crude indeed, flying mechanisms with little more than a reflex-response unit.'
Self-Healing Material Pulls Carbon Out Of The Air
'... could seal the punctures.'
IRL Glasses Block Screens, Limit Vision To Real Life
'If you couldn't see the ads, how would you know what was fashionable?'
Testing The Single-Person Spacecraft
'...the lower part of the suit was simply a rigid cylinder.'
Shapeshifting Materials Transform By Light
'Its lines wavered, flowed, and then painfully reformed.'
Fully Automated Farm Iron Ox Hydroponics
'Had these machines in some incredible fashion been provided with brains?'
BrainNet Social Network Of Brains
'I used my implant to tell MILLIE what we wanted and she took care of it'
Phil Nuyttnn's City Under The Sea
'Under the lower roof there was no water, but a clear and luminous atmosphere...'
IONITY Opens First 10 Fast-Charging Stations
'Recharge the batteries... in almost every town and village...'
Superstrong Multilayer Metal-Graphene Composite Material
Negligible increase in weight increased material strength by hundreds of times.
Deepfakes Imperil Democracy (George Orwell, Right Again)
'All history was a palimpsest, scraped clean and reinscribed exactly as often as was necessary.'
String Art Courtesy Of Robot Artist
The number of different ways to span a thread between a larger number of hooks is astronomical.
Still Wondering If You'd Work For A Robot Boss?
'This is all coming to you courtesy of the simstim unit wired into your deck, of course.'
World's First Autonomous Tram In Germany
What's it like for autonomous trams when they're turned off at night?
More SF in the News Stories
More Beyond Technovelgy science news stories