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"By the time I can take people out to where Hubble is looking, they won't be human anymore, by a long way."
- Larry Niven

Medical Use for Weightlessness  
  Early reference to the idea of using a weightless environment for medical purposes.  

"Now, Anti, don't be cynical. Doctors have an economic sense as well as the next person," said Docchi gravely. He turned to Cameron. "You see, after Anti grew too massive for her skeletal structure, doctors reasoned she'd be most comfortable in the absence of gravity. That was in the early days, before successful ship gravital units were developed. They put her on an interplanetary ship and kept transferring her before each landing.
From Accidental Flight, by W.F. Wallace.
Published by Galaxy in 1952
Additional resources -

In Jack Vance's excellent 1952 story Abercrombie Station, he uses the device of space as a place where morbidly obesity is not just doable, but fashionable and desirable.

A similar idea was used in the 1997 movie Contact (and maybe in the Saga novel from 1985), but weightlessness is not as important medically.

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