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"We were essentially being shell-shocked by rapid change. That was one of the things you needed science-fiction writers for back in the Sixties, because we could cope with the future."
- Peter Watts

Mutation  
  An organism that has come into being through genetic mutation.  

This is the first use in sf, perhaps the first use anywhere, of "mutation" as a noun.

There would be super-men, bodiless heads, pure brains; only to be changed by the last mutation of all into the protoplasm from which first it had sprung!
Technovelgy from The Man Who Evolved, by Edmond Hamilton.
Published by Wonder Stories in 1931
Additional resources -

The end result:


(The Man Who Evolved)

Compare to mutant from The 100th Generation by Nat Schachner.

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Additional resources:
  More Ideas and Technology from The Man Who Evolved
  More Ideas and Technology by Edmond Hamilton
  Tech news articles related to The Man Who Evolved
  Tech news articles related to works by Edmond Hamilton

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