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"One of the great tragedies of mankind is that morality has been hijacked by religion. So now people assume that religion and morality have a necessary connection."
- Arthur C. Clarke

Desubstantiation Effect  
  In interstellar space, the ship seems like the only material entity in the universe, leading to loneliness and anxiety.  

"Desubstantiation Effect" was a concept from astronautic psychology. Humans on Earth were surrounded by objects, and the image of the world in their subconscious was thus material and substantial. But in deep space, away from the Solar System, the stars were only distant points of light and the galaxy was nothing more than a luminous mist. To the senses and the mind, the world lost its materiality, and empty space dominated. A space voyagers subconscious image of the world thus became desubstantiated. This mental model was the baseline in astronautic psychology. Mentally, the ship became the only material entity in the universe. At sub-light speeds, the motion of the ship was undetectable, and the universe turned into one boundless, empty exhibition hall. Here, the stars were illusions, and the ship was the only object on display. This mental model brought with it a profound sense of loneliness, and it could cause the voyager to have subconscious delusions of being a "superobserver" toward the lone "object on display." This feeling of being completely exposed could lead to passivity and anxiety.

Thus, many of the negative psychological effects of deep-space flight were due to the extreme openness of the external environment. In West's extensive professional experience, it was extremely rare to develop claustrophobia the way Guan Yifan did.

Technovelgy from Death's End, by Cixin Liu.
Published by Tor in 2010
Additional resources -

Compare to space-sick from Ralph 124c 41 + (1911) by Hugo Gernsback, space madness from A Daring Trip to Mars (1931) by Max Valier, moon-terror from Star of Dreams (1941) by Jack Williamson, gravitation paralysis from The World With A Thousand Moons (1942) by Edmond Hamilton, Space Scurvy (Kenoalgia) from Sacred Martian Pig (1949) by Margaret Saint Clair and space phobia from Let 'em Breathe Space! (1953) by Lester del Rey.

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Additional resources:
  More Ideas and Technology from Death's End
  More Ideas and Technology by Cixin Liu
  Tech news articles related to Death's End
  Tech news articles related to works by Cixin Liu

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