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"A science fiction story is a story built around human beings, with a human problem and a human solution, which would not have happened at all without its scientific content."
- Theodore Sturgeon

Sapho Juice  
  Unique substance enhanced the cognitive performance of Mentats.  

"Thou shalt not make a machine in the likeness of a human mind." So we read in the Orange Catholic bible. But how will human beings pick up the slack? Cognitive enhancement is always appreciated - by Mentats.

High-energy liquid extracted from barrier roots of Ecaz. Commonly used by Mentats who claim it amplifies mental powers. Users develop deep ruby stains on mouth and lips.
From Dune, by Frank Herbert.
Published by Putnam in 1965
Additional resources -

Use of sapho caused noticeable changes in appearance:

Paul looked at his father, back to Hawat, suddenly conscious of the Mentat's great age, aware that the old man had served three generations of Atreides. Aged. It showed in the rheumy shine of the brown eyes, in the cheeks cracked and burned by exotic weathers, in the rounded curve of the shoulders and the thin set of his lips with the cranberry-colored stain of sapho juice.

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  More Ideas and Technology from Dune
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