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"I can remember when the first pulsars were discovered. I was able to go and sit down and listen to graduate students talking about what their theories, to explain what pulsars really were."
- Vernor Vinge

Thiotimoline  
  Remarkable substance dissolves about 1.12 seconds before contact with a solvent.  

It appears that at least one carbon atom in the molecule has chemical bonds that project into the future and the past.

Feinschreiber and Hravlek in their studies on the problem have contended that with increasing hydrophilism, the time of solution approaches zero. That this analysis is not entirely correct was shown when it was discovered that the compound thiotimoline will dissolve in water -in the proportions of 1 gm./ml.- in minus 1.12 seconds. That is, it will dissolve before the water is added...

irst attempts to measure the time of solution of thiotimoline quantitatively met with considerable difficulty because of the very negative nature of the value...

The question is, of course, instantly raised as to how the thiotimoline can "know" in advance whether the water will ultimately be added or not...

Since no method of laboratory synthesis of the substance has been devised, it may be practically obtained only through tedious isolation from its natural source, the bark of the shrub Rosacea Karlsbadensis rufo.

Technovelgy from The Endochronic Properties of Resublimated Thiotimoline, by Isaac Asimov.
Published by Astounding Science Fiction in 1948
Additional resources -

Thanks to Bakin's-Bits for insisting that I include this item.

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