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"It's also important to vary your stimuli. I always look for new things to shock the system. Just as you make muscles grow by shocking them, you make the mind grow by shocking it."
- Bart Kosko

Semuta  
  A combination of a specific drug and music, which penetrated to the deepest levels of consciousness.  

The drug is defined in the Appendix to Dune as "the second narcotic derivative (by crystal extraction) from the burned residue of elacca wood. The effect (described as timeless, sustained ecstasy) is elicited by certain atonal vibrations referred to as semuta music."

The guard captain, Iakin Nefud, squatted on a divan across the chamber, the stupor of semuta dullness in his flat face, the eerie wailing of semuta music around him. His own court sat near to do his bidding.
From Dune, by Frank Herbert.
Published by Putnam in 1965
Additional resources -

This idea strikes me as an anticipation of the rave experience, with atonal electronic dub for music, and any of an assortment of substances.

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Additional resources:
  More Ideas and Technology from Dune
  More Ideas and Technology by Frank Herbert
  Tech news articles related to Dune
  Tech news articles related to works by Frank Herbert

Semuta-related news articles:
  - 'Digital Drugs' (Like Herbert's Semuta?) Dismays Saudis

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